TY - JOUR
T1 - Beneficial impact of genome projects on tuberculosis control
AU - Randhawa, Gurvaneet S.
AU - Bishai, William R.
N1 - Funding Information:
The authors are grateful to Naomi Gauchet for her expert editorial assistance. The support of NIH grants AI36973, AI32856, AI43846 and a core scientist grant from the Sequella Global Tuberculosis Foundation is acknowledged gratefully.
PY - 2002
Y1 - 2002
N2 - The M. tuberculosis genome project is a landmark achievement in the history of TB research. The DNA sequence has provided valuable insights, along with a few surprises, into the complete genetic complement of M. tuberculosis. This information has been used to gain a better understanding of isoniazid-induced alteration in gene expression. It also has been used to construct a genealogy tree of different BCG strains, besides identifying genes that may be responsible for the human-specificity of M. tuberculosis. The impact of this project is far-reaching and in the next few years should yield innovative vaccines and therapeutic agents, besides aiding in the rapid and accurate diagnosis of TB.
AB - The M. tuberculosis genome project is a landmark achievement in the history of TB research. The DNA sequence has provided valuable insights, along with a few surprises, into the complete genetic complement of M. tuberculosis. This information has been used to gain a better understanding of isoniazid-induced alteration in gene expression. It also has been used to construct a genealogy tree of different BCG strains, besides identifying genes that may be responsible for the human-specificity of M. tuberculosis. The impact of this project is far-reaching and in the next few years should yield innovative vaccines and therapeutic agents, besides aiding in the rapid and accurate diagnosis of TB.
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U2 - 10.1016/S0891-5520(03)00050-3
DO - 10.1016/S0891-5520(03)00050-3
M3 - Review article
C2 - 11917811
AN - SCOPUS:0036128371
SN - 0891-5520
VL - 16
SP - 145
EP - 161
JO - Infectious disease clinics of North America
JF - Infectious disease clinics of North America
IS - 1
ER -