Beneficial effects of FK506 for experimental temporal lobe epilepsy

Tsutomu Nishimura; Hideki Imai; Yoshio Minabe; Akira Sawa; Nobumasa Kato

doi:10.1016/j.neures.2006.08.006

Beneficial effects of FK506 for experimental temporal lobe epilepsy

Tsutomu Nishimura, Hideki Imai, Yoshio Minabe, Akira Sawa, Nobumasa Kato

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.

Original language	English (US)
Pages (from-to)	386-390
Number of pages	5
Journal	Neuroscience Research
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/j.neures.2006.08.006
State	Published - Dec 2006

Keywords

Behavioral change
FK506
Kainic acid
Neuronal cell death
Temporal lobe epilepsy
Trimethyltin

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neures.2006.08.006

Cite this

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title = "Beneficial effects of FK506 for experimental temporal lobe epilepsy",

abstract = "FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.",

keywords = "Behavioral change, FK506, Kainic acid, Neuronal cell death, Temporal lobe epilepsy, Trimethyltin",

author = "Tsutomu Nishimura and Hideki Imai and Yoshio Minabe and Akira Sawa and Nobumasa Kato",

note = "Funding Information: We appreciate the excellent assistance of Yukiko Lema for organizing figures. This study was performed through Special Coordination Funds for Promoting Science and Technology from the Ministry of Education, Culture, Sports, Science and Technology, Japan.",

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AU - Nishimura, Tsutomu

AU - Imai, Hideki

AU - Minabe, Yoshio

AU - Sawa, Akira

AU - Kato, Nobumasa

N1 - Funding Information: We appreciate the excellent assistance of Yukiko Lema for organizing figures. This study was performed through Special Coordination Funds for Promoting Science and Technology from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2006/12

Y1 - 2006/12

N2 - FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.

AB - FK506, originally classified as an immunosuppressant, may also be implicated in some events in the central nervous system. FK506 elicits both neuroprotective and neurotrophic effects in vitro. FK506 is neuroprotective for focal cerebral ischemia, but it is not clear whether FK506 has neuroprotective effects for other brain diseases. In this study, we investigated possible neuroprotective effects of FK506 in experimental temporal lobe epilepsy (TLE) induced by kainic acid (KA) or trimethyltin (TMT). In rat models, we observed marked protection against seizures, abnormal behaviors, and accompanying delayed neuronal damage in the hippocampus by the systemic injection of FK506.

KW - Behavioral change

KW - FK506

KW - Kainic acid

KW - Neuronal cell death

KW - Temporal lobe epilepsy

KW - Trimethyltin

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Beneficial effects of FK506 for experimental temporal lobe epilepsy

Abstract

Keywords

ASJC Scopus subject areas

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