Behavioral and psychosocial responses to genomic testing for colorectal cancer risk

Kristi D. Graves; Kara Grace Leventhal; Rachel Nusbaum; Yasmin Salehizadeh; Gillian W. Hooker; Beth N. Peshkin; Morgan Butrick; William Tuong; Jeena Mathew; David Goerlitz; Mary B. Fishman; Peter G. Shields; Marc D. Schwartz

doi:10.1016/j.ygeno.2013.04.002

Behavioral and psychosocial responses to genomic testing for colorectal cancer risk

Kristi D. Graves, Kara Grace Leventhal, Rachel Nusbaum, Yasmin Salehizadeh, Gillian W. Hooker, Beth N. Peshkin, Morgan Butrick, William Tuong, Jeena Mathew, David Goerlitz, Mary B. Fishman, Peter G. Shields, Marc D. Schwartz

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a translational genomic pilot study to evaluate the impact of genomic information related to colorectal cancer (CRC) risk on psychosocial, behavioral and communication outcomes. In 47 primary care participants, 96% opted for testing of three single nucleotide polymorphisms (SNPs) related to CRC risk. Participants averaged 2.5 of 6 possible SNP risk alleles (10% lifetime risk). At 3-months, participants did not report significant increases in cancer worry/distress; over half reported physical activity and dietary changes. SNP risk scores were unrelated to behavior change at 3-months. Many participants (64%) shared their SNP results, including 28% who shared results with a physician. In this pilot, genomic risk education, including discussion of other risk factors, appeared to impact patients' health behaviors, regardless of the level of SNP risk. Future work can compare risk education with and without SNP results to evaluate if SNP information adds value to existing approaches.

Original language	English (US)
Pages (from-to)	123-130
Number of pages	8
Journal	Genomics
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.ygeno.2013.04.002
State	Published - Aug 2013
Externally published	Yes

Keywords

Behavior change
Colorectal cancer risk
Genomic education
SNP testing
Translational genomic research

ASJC Scopus subject areas

Genetics

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10.1016/j.ygeno.2013.04.002

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title = "Behavioral and psychosocial responses to genomic testing for colorectal cancer risk",

abstract = "We conducted a translational genomic pilot study to evaluate the impact of genomic information related to colorectal cancer (CRC) risk on psychosocial, behavioral and communication outcomes. In 47 primary care participants, 96% opted for testing of three single nucleotide polymorphisms (SNPs) related to CRC risk. Participants averaged 2.5 of 6 possible SNP risk alleles (10% lifetime risk). At 3-months, participants did not report significant increases in cancer worry/distress; over half reported physical activity and dietary changes. SNP risk scores were unrelated to behavior change at 3-months. Many participants (64%) shared their SNP results, including 28% who shared results with a physician. In this pilot, genomic risk education, including discussion of other risk factors, appeared to impact patients' health behaviors, regardless of the level of SNP risk. Future work can compare risk education with and without SNP results to evaluate if SNP information adds value to existing approaches.",

keywords = "Behavior change, Colorectal cancer risk, Genomic education, SNP testing, Translational genomic research",

author = "Graves, {Kristi D.} and Leventhal, {Kara Grace} and Rachel Nusbaum and Yasmin Salehizadeh and Hooker, {Gillian W.} and Peshkin, {Beth N.} and Morgan Butrick and William Tuong and Jeena Mathew and David Goerlitz and Fishman, {Mary B.} and Shields, {Peter G.} and Schwartz, {Marc D.}",

year = "2013",

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doi = "10.1016/j.ygeno.2013.04.002",

language = "English (US)",

volume = "102",

pages = "123--130",

journal = "Genomics",

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AU - Graves, Kristi D.

AU - Leventhal, Kara Grace

AU - Nusbaum, Rachel

AU - Salehizadeh, Yasmin

AU - Hooker, Gillian W.

AU - Peshkin, Beth N.

AU - Butrick, Morgan

AU - Tuong, William

AU - Mathew, Jeena

AU - Goerlitz, David

AU - Fishman, Mary B.

AU - Shields, Peter G.

AU - Schwartz, Marc D.

PY - 2013/8

Y1 - 2013/8

N2 - We conducted a translational genomic pilot study to evaluate the impact of genomic information related to colorectal cancer (CRC) risk on psychosocial, behavioral and communication outcomes. In 47 primary care participants, 96% opted for testing of three single nucleotide polymorphisms (SNPs) related to CRC risk. Participants averaged 2.5 of 6 possible SNP risk alleles (10% lifetime risk). At 3-months, participants did not report significant increases in cancer worry/distress; over half reported physical activity and dietary changes. SNP risk scores were unrelated to behavior change at 3-months. Many participants (64%) shared their SNP results, including 28% who shared results with a physician. In this pilot, genomic risk education, including discussion of other risk factors, appeared to impact patients' health behaviors, regardless of the level of SNP risk. Future work can compare risk education with and without SNP results to evaluate if SNP information adds value to existing approaches.

AB - We conducted a translational genomic pilot study to evaluate the impact of genomic information related to colorectal cancer (CRC) risk on psychosocial, behavioral and communication outcomes. In 47 primary care participants, 96% opted for testing of three single nucleotide polymorphisms (SNPs) related to CRC risk. Participants averaged 2.5 of 6 possible SNP risk alleles (10% lifetime risk). At 3-months, participants did not report significant increases in cancer worry/distress; over half reported physical activity and dietary changes. SNP risk scores were unrelated to behavior change at 3-months. Many participants (64%) shared their SNP results, including 28% who shared results with a physician. In this pilot, genomic risk education, including discussion of other risk factors, appeared to impact patients' health behaviors, regardless of the level of SNP risk. Future work can compare risk education with and without SNP results to evaluate if SNP information adds value to existing approaches.

KW - Behavior change

KW - Colorectal cancer risk

KW - Genomic education

KW - SNP testing

KW - Translational genomic research

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Behavioral and psychosocial responses to genomic testing for colorectal cancer risk

Abstract

Keywords

ASJC Scopus subject areas

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