Beat to beat variability in cardiovascular variables: Noise or music?

Marvin L. Appel; Ronald D. Berger; J. Philip Saul; Joseph M. Smith; Richard J. Cohen

doi:10.1016/0735-1097(89)90408-7

Beat to beat variability in cardiovascular variables: Noise or music?

Marvin L. Appel, Ronald D. Berger, J. Philip Saul, Joseph M. Smith, Richard J. Cohen

Research output: Contribution to journal › Article › peer-review

402 Scopus citations

Abstract

Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.

Original language	English (US)
Pages (from-to)	1139-1148
Number of pages	10
Journal	Journal of the American College of Cardiology
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/0735-1097(89)90408-7
State	Published - Nov 1 1989
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0735-1097(89)90408-7

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title = "Beat to beat variability in cardiovascular variables: Noise or music?",

abstract = "Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.",

author = "Appel, {Marvin L.} and Berger, {Ronald D.} and Saul, {J. Philip} and Smith, {Joseph M.} and Cohen, {Richard J.}",

note = "Funding Information: From the Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts. This work was supported by Grant IROI-HL39291-01,f rom the National Institutes of Health, Bethesda, Maryland, Grant NAGW-988, from the National Aeronautics and Space Administration of Washington, D.C., a grant from the Whitaker Foundation, Mechanicsburg, Pennsylvania; a grant from the Johnson and Johnson HST Research Fund, Cambridge, Massachusetts and a grant from the Cohn Medical Instrument Co., South Plainfield, New Jersey. M. Appel is grateful for support from the Fannie and John Hertz Foundation, Livermore, California. Manuscript received March 3 I, 1989, accepted June 7. 1989.",

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doi = "10.1016/0735-1097(89)90408-7",

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T2 - Noise or music?

AU - Appel, Marvin L.

AU - Berger, Ronald D.

AU - Saul, J. Philip

AU - Smith, Joseph M.

AU - Cohen, Richard J.

N1 - Funding Information: From the Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts. This work was supported by Grant IROI-HL39291-01,f rom the National Institutes of Health, Bethesda, Maryland, Grant NAGW-988, from the National Aeronautics and Space Administration of Washington, D.C., a grant from the Whitaker Foundation, Mechanicsburg, Pennsylvania; a grant from the Johnson and Johnson HST Research Fund, Cambridge, Massachusetts and a grant from the Cohn Medical Instrument Co., South Plainfield, New Jersey. M. Appel is grateful for support from the Fannie and John Hertz Foundation, Livermore, California. Manuscript received March 3 I, 1989, accepted June 7. 1989.

PY - 1989/11/1

Y1 - 1989/11/1

N2 - Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.

AB - Cardiovascular variables such as heart rate, arterial blood pressure, stroke volume and the shape of electrocardiographic complexes all fluctuate on a beat to beat basis. These fluctuations have traditionally been ignored or, at best, treated as noise to be averaged out. The variability in cardiovascular signals reflects the homeodynamic interplay between perturbations to cardiovascular function and the dynamic response of the cardiovascular regulatory systems. Modern signal processing techniques provide a means of analyzing beat to beat fluctuations in cardiovascular signals, so as to permit a quantitative, noninvasive or minimally invasive method of assessing closed loop hemodynamic regulation and cardiac electrical stability. This method promises to provide a new approach to the clinical diagnosis and management of alterations in cardiovascular regulation and stability.

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Beat to beat variability in cardiovascular variables: Noise or music?

Abstract

ASJC Scopus subject areas

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