Basophils in Inflammation and Allergy Drug Design

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationInflammation and Allergy Drug Design
Number of pages15
ISBN (Print)9781444330144
StatePublished - Jul 27 2011


  • Basophil function modulation - receptors in basophils, inducing mediator release, inducing cytokine release
  • Basophils and innate immune response - IgE-mediated response in basophils, the way cells can be stimulated to secrete mediators
  • Basophils in inflammation - and allergy drug design, basophils versus mast cells
  • Cytokine release, coincident - with degranulation and rapid
  • Functionally active ligands (or their receptors) - on human basophils
  • IL-3, regulating pre-Golgi pool of FcεRIα
  • Mediators of inflammatory response - three classes of mediators, from basophils and metabolites of arachidonic acid
  • Roles of basophils in immune response - classic primary immune response (T cells, B cells, and antigen-presenting cells [APCs])
  • Syk expression, a weak correlation - with levels of Syk mRNA, regulating Syk in basophils
  • Syk regulation on basophils - opportunity for selective manipulation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

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