Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults

Bradley R. King, Jost Julian Rumpf, Elvire Verbaanderd, Kirstin F. Heise, Nina Dolfen, Stefan Sunaert, Julien Doyon, Joseph Classen, Dante Mantini, Nicolaas A.J. Puts, Richard A.E. Edden, Geneviève Albouy, Stephan P. Swinnen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma-aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging-related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting-state functional connectivity in the brains of healthy older participants. Thirty-six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA-edited magnetic resonance spectroscopy of the sensorimotor cortex and resting-state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task-relevant regions. However, changes in GABA levels from the baseline to post-learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task-relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning-related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post-learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults.

Original languageEnglish (US)
Pages (from-to)3680-3695
Number of pages16
JournalHuman Brain Mapping
Issue number13
StatePublished - Sep 1 2020


  • aging
  • functional connectivity
  • functional neuroimaging
  • gamma-aminobutyric acid
  • motor learning

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults'. Together they form a unique fingerprint.

Cite this