TY - JOUR
T1 - Baseline Demographics and Clinical Characteristics Among 3471 US Patients Hospitalized with COVID-19 and Pulmonary Involvement
T2 - A Retrospective Study
AU - Best, Jennie H.
AU - Mohan, Shalini V.
AU - Kong, Amanda M.
AU - Patel, Krish
AU - Pagel, John M.
AU - Ivanov, Boris
AU - Brawley, Otis W.
AU - Jariwala-Parikh, Krutika
AU - Zazzali, James L.
AU - Pauk, John
N1 - Funding Information:
This study and the Rapid Service and Open Access Fees were funded by Genentech, Inc., South San Francisco, CA. Genentech, Inc., was involved in the design of the study; analysis and interpretation of the data; preparation, review, and approval of the manuscript; and decision to submit the manuscript for publication. Support for third-party writing assistance for this manuscript, provided by Claire Stedden, PhD, of Health Interactions, Inc., was provided by Genentech, Inc. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. All authors had access to the data, provided critical feedback, and contributed to the writing of the manuscript. JHB and SVM conceived and designed the study. AMK provided subject matter expertise, and BI and KJ-P conducted programming and data analysis support. JHB, SVM, AMK, JMP, KP, JP, OWB, and JLZ contributed to the interpretation of the results. Jennie H. Best, Shalini V. Mohan, and James L. Zazzali are employees and shareholders of Genentech, Inc. Amanda M. Kong, Boris Ivanov, and Krutika Jariwala-Parikh are employees of IBM Watson Health. Krish Patel declares consultation honoraria from Genentech, Inc., outside of the submitted work. John M. Pagel, Otis W. Brawley and John Pauk have nothing to disclose. This was a retrospective, observational study and all study data were deidentified and fully compliant with Health Insurance Portability and Accountability Act Regulations (45 CFR 164.514e); therefore, approval from an institutional review board was not required and informed consent was not obtained. IBM Explorys is a proprietary database. The database is available from IBM Watson Health, but restrictions apply to the availability of these data and therefore they are not publicly available. Please contact AMK ([email protected]) for information on the Explorys data.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Introduction: Coronavirus disease 2019 (COVID-19) can present as a range of symptoms, from mild to critical; lower pulmonary involvement, including pneumonia, is often associated with severe and critical cases. Understanding the baseline characteristics of patients hospitalized with COVID-19 illness is essential for effectively targeting clinical care and allocating resources. This study aimed to describe baseline demographics and clinical characteristics of US patients hospitalized with COVID-19 and pulmonary involvement. Methods: US patients with COVID-19 and pulmonary involvement during an inpatient admission from December 1, 2019, to May 20, 2020, were identified using the IBM Explorys® electronic health records database. Baseline (up to 12 months prior to first COVID-19 hospitalization) demographics and clinical characteristics and preadmission (14 days to 1 day prior to admission) pulmonary diagnoses were assessed. Patients were stratified by sex, age, race, and geographic region. Results: Overall, 3471 US patients hospitalized with COVID-19 and pulmonary involvement were included. The mean (SD) age was 63.5 (16.3) years; 51.2% of patients were female, 55.0% African American, 81.6% from the South, and 16.8% from the Midwest. The most common comorbidities included hypertension (27.7%), diabetes (17.3%), hyperlipidemia (16.3%), and obesity (9.7%). Cough (27.3%) and dyspnea (15.2%) were the most common preadmission pulmonary symptoms. African American patients were younger (mean [SD], 62.5 [15.4] vs. 67.8 [6.2]) with higher mean (SD) body mass index (33.66 [9.46] vs. 30.42 [7.86]) and prevalence of diabetes (19.8% vs. 16.7%) and lower prevalence of chronic obstructive pulmonary disease (5.6% vs. 8.2%) and smoking/tobacco use (28.1% vs. 37.2%) than White patients. Conclusions: Among US patients primarily from the South and Midwest hospitalized with COVID-19 and pulmonary involvement, the most common comorbidities were hypertension, diabetes, hyperlipidemia, and obesity. Differences observed between African American and White patients should be considered in the context of the complex factors underlying racial disparities in COVID-19.
AB - Introduction: Coronavirus disease 2019 (COVID-19) can present as a range of symptoms, from mild to critical; lower pulmonary involvement, including pneumonia, is often associated with severe and critical cases. Understanding the baseline characteristics of patients hospitalized with COVID-19 illness is essential for effectively targeting clinical care and allocating resources. This study aimed to describe baseline demographics and clinical characteristics of US patients hospitalized with COVID-19 and pulmonary involvement. Methods: US patients with COVID-19 and pulmonary involvement during an inpatient admission from December 1, 2019, to May 20, 2020, were identified using the IBM Explorys® electronic health records database. Baseline (up to 12 months prior to first COVID-19 hospitalization) demographics and clinical characteristics and preadmission (14 days to 1 day prior to admission) pulmonary diagnoses were assessed. Patients were stratified by sex, age, race, and geographic region. Results: Overall, 3471 US patients hospitalized with COVID-19 and pulmonary involvement were included. The mean (SD) age was 63.5 (16.3) years; 51.2% of patients were female, 55.0% African American, 81.6% from the South, and 16.8% from the Midwest. The most common comorbidities included hypertension (27.7%), diabetes (17.3%), hyperlipidemia (16.3%), and obesity (9.7%). Cough (27.3%) and dyspnea (15.2%) were the most common preadmission pulmonary symptoms. African American patients were younger (mean [SD], 62.5 [15.4] vs. 67.8 [6.2]) with higher mean (SD) body mass index (33.66 [9.46] vs. 30.42 [7.86]) and prevalence of diabetes (19.8% vs. 16.7%) and lower prevalence of chronic obstructive pulmonary disease (5.6% vs. 8.2%) and smoking/tobacco use (28.1% vs. 37.2%) than White patients. Conclusions: Among US patients primarily from the South and Midwest hospitalized with COVID-19 and pulmonary involvement, the most common comorbidities were hypertension, diabetes, hyperlipidemia, and obesity. Differences observed between African American and White patients should be considered in the context of the complex factors underlying racial disparities in COVID-19.
KW - Baseline characteristics
KW - COVID-19
KW - Coronavirus
KW - Demographics
KW - Hospitalized
KW - Infectious disease
KW - Pulmonary involvement
UR - http://www.scopus.com/inward/record.url?scp=85092502063&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092502063&partnerID=8YFLogxK
U2 - 10.1007/s12325-020-01510-y
DO - 10.1007/s12325-020-01510-y
M3 - Article
C2 - 33044691
AN - SCOPUS:85092502063
SN - 0741-238X
VL - 37
SP - 4981
EP - 4995
JO - Advances in Therapy
JF - Advances in Therapy
IS - 12
ER -