Baseline Characteristics Associated with Good Collateral Status Using Hypoperfusion Index as an Outcome

Omar Hamam, Tushar Garg, Omar Elmandouh, Richard Wang, Alperen Aslan, Amara Ahmed, Abdallah Moustafa, Vivek Yedavalli

Research output: Contribution to journalArticlepeer-review


Up to 30% of ischemic stroke cases are due to large vessel occlusion (LVO), causing significant morbidity. Studies have shown that the collateral circulation of patients with acute ischemic stroke (AIS) secondary to LVO can predict their clinical and radiological outcomes. The aim of this study is to identify baseline patient characteristics that can help predict the collateral status of these patients for improved triage. In this IRB approved retrospective study, consecutive patients presenting with AIS secondary to anterior circulation LVO were identified between September 2019 and August 2021. The baseline patient characteristics, laboratory values, imaging features and outcomes were collected using a manual chart review. From the 181 consecutive patients initially reviewed, 54 were confirmed with a clinical diagnosis of AIS and anterior circulation LVO. In patients with poor collateral status, the body mass index (BMI) was found to be significantly lower compared to those with good collateral status (26.4 ± 5.6 vs. 31.7 ± 12.3; p = 0.045). BMI of >35 kg/m2 was found to predict the presence of good collateral status. Age was found to be significantly higher (70.5 ± 9.6 vs. 58.9 ± 15.6; p = 0.034) in patients with poor collateral status and M1 strokes associated with older age and BMI.

Original languageEnglish (US)
Pages (from-to)1885-1894
Number of pages10
Issue number4
StatePublished - Aug 2022


  • acute ischemic
  • collaterals status
  • hypoperfusion
  • hypoperfusion index

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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