Basal forebrain neurons provide major cholinergic innervation of primate neocortex

Robert G. Struble; John Lehmann; Susan J. Mitchell; Michael McKinney; Donald L. Price; Joseph T. Coyle; Mahlon R. DeLong

doi:10.1016/0304-3940(86)90193-X

Basal forebrain neurons provide major cholinergic innervation of primate neocortex

Robert G. Struble, John Lehmann, Susan J. Mitchell, Michael McKinney, Donald L. Price, Joseph T. Coyle, Mahlon R. DeLong

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	Neuroscience Letters
Volume	66
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90193-X
State	Published - May 15 1986

Keywords

basal forebrain
choline acetyltransferase
ibotenic acid
monkey
neocortex

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(86)90193-X

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@article{92010f286f8341bd897f1f529645d291,

title = "Basal forebrain neurons provide major cholinergic innervation of primate neocortex",

abstract = "In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.",

keywords = "basal forebrain, choline acetyltransferase, ibotenic acid, monkey, neocortex",

author = "Struble, {Robert G.} and John Lehmann and Mitchell, {Susan J.} and Michael McKinney and Price, {Donald L.} and Coyle, {Joseph T.} and DeLong, {Mahlon R.}",

note = "Funding Information: grants f r o mt h e U.S. Public Health Service (NIH NS 20471, MH 08868, MH 26654, MH 00125 and",

year = "1986",

month = may,

day = "15",

doi = "10.1016/0304-3940(86)90193-X",

language = "English (US)",

volume = "66",

pages = "215--220",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

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T1 - Basal forebrain neurons provide major cholinergic innervation of primate neocortex

AU - Struble, Robert G.

AU - Lehmann, John

AU - Mitchell, Susan J.

AU - McKinney, Michael

AU - Price, Donald L.

AU - Coyle, Joseph T.

AU - DeLong, Mahlon R.

N1 - Funding Information: grants f r o mt h e U.S. Public Health Service (NIH NS 20471, MH 08868, MH 26654, MH 00125 and

PY - 1986/5/15

Y1 - 1986/5/15

N2 - In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.

AB - In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.

KW - basal forebrain

KW - choline acetyltransferase

KW - ibotenic acid

KW - monkey

KW - neocortex

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ER -

Basal forebrain neurons provide major cholinergic innervation of primate neocortex

Abstract

Keywords

ASJC Scopus subject areas

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