Basal forebrain neurons provide major cholinergic innervation of primate neocortex

Robert G. Struble, John Lehmann, Susan J. Mitchell, Michael McKinney, Donald L. Price, Joseph T. Coyle, Mahlon R. DeLong

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalNeuroscience Letters
Issue number2
StatePublished - May 15 1986


  • basal forebrain
  • choline acetyltransferase
  • ibotenic acid
  • monkey
  • neocortex

ASJC Scopus subject areas

  • Neuroscience(all)


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