Barrenness vanquished: The legacy of Lesley Brown

Eli Y. Adashi, Howard W. Jones

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Prior to 1978, the therapeutic offerings available to couples afflicted with infertility were painfully limited. Indeed, there was precious little one could offer Lesley and John Brown in their desperation. Anovulatory infertility was managed with ovulation induction using Clomiphene Citrate and Human Menopausal Gonadotropins. Anatomic infertility was addressed by increasingly sophisticated if marginally effective microsurgical approaches. The therapy of male infertility, still in its infancy, was commonly handled through cervical or intrauterine insemination including the use of donor sperm. The road traveled by Mrs. Brown radically altered this hope-limited landscape. A trailblazer to the millions who followed, Mrs. Brown played a key role in the abolition of the scourge of infertility. In this communication we trace in some detail the singular story of Mrs. Lesley Brown and the all-important legacy thereof. In doing so, we wish to pay tribute to this remarkable individual and her contributions to one of the most compelling scientific and medical breakthroughs of the 20th century.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalHuman Fertility
Issue number2
StatePublished - Jun 2013
Externally publishedYes


  • Barrenness
  • IVF
  • In vitro fertilization
  • Infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


Dive into the research topics of 'Barrenness vanquished: The legacy of Lesley Brown'. Together they form a unique fingerprint.

Cite this