Banded structures in collagen vitrigels for corneal injury repair

Zhiyong Xia, Xiomara Calderón-Colón, Russell McCally, Jeffrey Maranchi, Lixia Rong, Benjamin Hsiao, Jennifer Elisseeff, Morgana Trexler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


There is a growing interest in using collagen vitrigels for corneal injury repair. We recently reported the synthesis and thermal denaturation behavior of these gels. In this paper, the banded structure in these vitrified gels is studied by small-angle X-ray scattering (SAXS) one-dimensional (1-D) correlation function analysis and transmission electron microscopy (TEM). Results demonstrate that the collagen vitrigel possess banded structures similar to those of the starting type I collagen, with an average D-spacing of 64 nm (by SAXS) or 57 nm (by TEM). A combination of SAXS 1-D correlation function analyses and TEM show that overlap and gap distances ranged from 30 to 33 nm and from 23 to 25 nm, respectively. Changing the vitrification condition does not impact on the banded structure significantly.

Original languageEnglish (US)
Pages (from-to)3615-3619
Number of pages5
JournalActa Biomaterialia
Issue number8
StatePublished - Aug 2014


  • Banded structure
  • Corneal injury repair
  • D-Spacing
  • Small-angle X-ray scattering
  • collagen vitrigel

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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