Band 1p36 abnormalities and t(1;17) in ovarian carcinoma

Floyd H. Thompson, Raymond Taetle, Jeffrey M. Trent, Yun Liu, Kathy Massey-Brown, Katherine M. Scott, Ronald S. Weinstein, Julia C. Emerson, David S. Alberts, Mark A. Nelson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3- specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17[t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas.

Original languageEnglish (US)
Pages (from-to)106-110
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number2
StatePublished - Jul 15 1997
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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