TY - JOUR
T1 - Bancroftian filariasis in Haiti
T2 - Preliminary characterization of the immunological responsiveness of microfilaremic individuals
AU - Lammie, P. J.
AU - Leiva, L. E.
AU - Ruff, A. J.
AU - Eberhard, M. L.
AU - Lowrie, R. C.
AU - Katz, S. P.
PY - 1988
Y1 - 1988
N2 - Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftial filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as 'responders' to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio > 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P < 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
AB - Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftial filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as 'responders' to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio > 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P < 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
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U2 - 10.4269/ajtmh.1988.38.125
DO - 10.4269/ajtmh.1988.38.125
M3 - Article
C2 - 3277457
AN - SCOPUS:0023836167
SN - 0002-9637
VL - 38
SP - 125
EP - 129
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -