BAF: Roles in chromatin, nuclear structure and retrovirus integration

Miriam Segura-Totten, Katherine L. Wilson

Research output: Contribution to journalReview articlepeer-review

122 Scopus citations

Abstract

Barrier-to-autointegration factor (BAF) is an essential protein that is highly conserved in metazoan evolution. BAF binds directly to double-stranded DNA, nuclear LEM-domain proteins, lamin A and transcription activators. BAF is also a host cell component of retroviral pre-integration complexes. BAF binds matrix, a retroviral protein, and facilitates efficient retroviral DNA integration in vitro through unknown mechanisms. New findings suggest that BAF has structural roles in nuclear assembly and chromatin organization, represses gene expression and might interlink chromatin structure, nuclear architecture and gene regulation in metazoans.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalTrends in Cell Biology
Volume14
Issue number5
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Cell Biology

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