Back in the water: The return of the inositol phosphates

Robin F. Irvine, Michael J. Schell

Research output: Contribution to journalReview articlepeer-review

500 Scopus citations


Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number5
StatePublished - May 2001
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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