BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid

Soraia Barão; Lujia Zhou; Katarzyna Adamczuk; Tine Vanhoutvin; Fred van Leuven; David Demedts; Anne Catherine Vijverman; Xavier Bossuyt; Rik Vandenberghe; Bart De Strooper

doi:10.2174/15672050113109990138

BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid

Soraia Barão, Lujia Zhou, Katarzyna Adamczuk, Tine Vanhoutvin, Fred van Leuven, David Demedts, Anne Catherine Vijverman, Xavier Bossuyt, Rik Vandenberghe, Bart De Strooper

Research output: Contribution to journal › Article › peer-review

Abstract

Previous studies have investigated the activity and protein levels of BACE1, the β3-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.

Original language	English (US)
Pages (from-to)	671-678
Number of pages	8
Journal	Current Alzheimer Research
Volume	10
Issue number	7
DOIs	https://doi.org/10.2174/15672050113109990138
State	Published - 2013
Externally published	Yes

Keywords

Alzheimer's disease
BACE1
Biomarker
Human CSF
Neurodegeneration
Sandwich ELISA

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.2174/15672050113109990138

Cite this

@article{a2785e9c63fc4803b3249137700c221e,

title = "BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid",

abstract = "Previous studies have investigated the activity and protein levels of BACE1, the β3-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.",

keywords = "Alzheimer's disease, BACE1, Biomarker, Human CSF, Neurodegeneration, Sandwich ELISA",

author = "Soraia Bar{\~a}o and Lujia Zhou and Katarzyna Adamczuk and Tine Vanhoutvin and {van Leuven}, Fred and David Demedts and Vijverman, {Anne Catherine} and Xavier Bossuyt and Rik Vandenberghe and {De Strooper}, Bart",

year = "2013",

doi = "10.2174/15672050113109990138",

language = "English (US)",

volume = "10",

pages = "671--678",

journal = "Current Alzheimer Research",

issn = "1567-2050",

publisher = "Bentham Science Publishers B.V.",

number = "7",

}

TY - JOUR

T1 - BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid

AU - Barão, Soraia

AU - Zhou, Lujia

AU - Adamczuk, Katarzyna

AU - Vanhoutvin, Tine

AU - van Leuven, Fred

AU - Demedts, David

AU - Vijverman, Anne Catherine

AU - Bossuyt, Xavier

AU - Vandenberghe, Rik

AU - De Strooper, Bart

PY - 2013

Y1 - 2013

N2 - Previous studies have investigated the activity and protein levels of BACE1, the β3-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.

AB - Previous studies have investigated the activity and protein levels of BACE1, the β3-secretase, in the brain and cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients, however, results remain contradictory. We present here a highly specific and sensitive BACE1 ELISA, which allows measuring accurately BACE1 levels in human samples. We find that BACE1 levels in CSF of AD patients and other neurological disorder (OND) patients are slightly increased when compared to those of a non-neurological disorder control group (NND). BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration.

KW - Alzheimer's disease

KW - BACE1

KW - Biomarker

KW - Human CSF

KW - Neurodegeneration

KW - Sandwich ELISA

UR - http://www.scopus.com/inward/record.url?scp=84888225102&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888225102&partnerID=8YFLogxK

U2 - 10.2174/15672050113109990138

DO - 10.2174/15672050113109990138

M3 - Article

C2 - 23566348

AN - SCOPUS:84888225102

SN - 1567-2050

VL - 10

SP - 671

EP - 678

JO - Current Alzheimer Research

JF - Current Alzheimer Research

IS - 7

ER -

BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this