B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Gabriel L. Sica; In Hak Choi; Gefeng Zhu; Koji Tamada; Sheng Dian Wang; Hideto Tamura; Andrei I. Chapoval; Dallas B. Flies; Jürgen Bajorath; Lieping Chen

doi:10.1016/S1074-7613(03)00152-3

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Gabriel L. Sica, In Hak Choi, Gefeng Zhu, Koji Tamada, Sheng Dian Wang, Hideto Tamura, Andrei I. Chapoval, Dallas B. Flies, Jürgen Bajorath, Lieping Chen

Research output: Contribution to journal › Article › peer-review

524 Scopus citations

Abstract

We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

Original language	English (US)
Pages (from-to)	849-861
Number of pages	13
Journal	Immunity
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/S1074-7613(03)00152-3
State	Published - Jun 1 2003
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases
Immunology

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10.1016/S1074-7613(03)00152-3

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title = "B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity",

abstract = "We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.",

author = "Sica, {Gabriel L.} and Choi, {In Hak} and Gefeng Zhu and Koji Tamada and Wang, {Sheng Dian} and Hideto Tamura and Chapoval, {Andrei I.} and Flies, {Dallas B.} and J{\"u}rgen Bajorath and Lieping Chen",

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T1 - B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

AU - Sica, Gabriel L.

AU - Choi, In Hak

AU - Zhu, Gefeng

AU - Tamada, Koji

AU - Wang, Sheng Dian

AU - Tamura, Hideto

AU - Chapoval, Andrei I.

AU - Flies, Dallas B.

AU - Bajorath, Jürgen

AU - Chen, Lieping

PY - 2003/6/1

Y1 - 2003/6/1

N2 - We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

AB - We identify a B7 family molecule, B7-H4, by protein sequence analysis and comparative molecular modeling. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

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JO - Immunity

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ER -

B7-H4, a Molecule of the B7 Family, Negatively Regulates T Cell Immunity

Abstract

ASJC Scopus subject areas

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