@article{8b55953904ab4b3991e5c98f566cea0b,
title = "Azithromycin for treatment of severe Cryptosporidium diarrhea in two children with cancer",
abstract = "Two children with cancer received azithromycin for Cryptosporidium-associated diarrhea that was unresponsive to supportive care. One child had choleriform diarrhea requiring daily fluid replacement of up to 65% of his total body weight; the other had protracted diarrhea and wasting. In both cases, administration of azithromycin was followed by prompt clinical imporvement.",
author = "Vargas, {Sergio L.} and Shenep, {Jerry L.} and Flynn, {Patricia M.} and Pui, {Ching Hon} and Santana, {Victor M.} and Hughes, {Walter T.}",
note = "Funding Information: Supported by Cancer Center Support CORE grant P30 CA 21765, National Cancer Institute grant P01 CA 23099, and American Lebanese Syrian Associated Charities (ALSAC). Dr. Vargas is the recipient of a National Scholarship Award of Chile (Ministerio de Planificaci6n Nacional de Chile). Submitted for publication Jan. 26, 1993; accepted March 9, 1993. Reprint requests: Sergio L. Vargas, MD, Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105-2794. Copyright 9 1993 by Mosby-Year Book, Inc. 0022-3476/93/$1.00 + .10 9/26/47155 Best known as a pathogen in patients with the acquired immunodeficiency syndrom@ Cryptosporidium species can also cause life-threatening illness in other immunocompromised hosts, including patients with cancer who are receiving chemotherapy. 2, 3 Serious Cryptosporidium infection is usually manifested as chronic debilitating diarrhea. Although several therapeutic approaches have been investigated, none has proved effective. 2, 4 Drugs investigated as possible therapies for Crypto-sporidiurn infection include diloxanide furoate, furazoli-",
year = "1993",
month = jul,
doi = "10.1016/S0022-3476(05)81562-8",
language = "English (US)",
volume = "123",
pages = "154--156",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "1",
}