Avoiding DEET through insect gustatory receptors

Youngseok Lee, Sang Hoon Kim, Craig Montell

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


DEET is the most widely used insect repellent worldwide. In Drosophila olfactory receptor neurons (ORNs), DEET is detected through a mechanism employing the olfactory receptor, OR83b. However, it is controversial as to whether ORNs respond directly to DEET or whether DEET blocks the response to attractive odors. Here, we showed that DEET suppressed feeding behavior in Drosophila, and this effect was mediated by gustatory receptor neurons (GRNs). DEET was potent in suppressing feeding as

Original languageEnglish (US)
Pages (from-to)555-561
Number of pages7
Issue number4
StatePublished - 2010


  • Molneuro
  • Signaling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)


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