Autosomal dominant polycystic kidney disease: A two-hit model

Gregory G. Germino

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The clinical and histopathologic variability of this common genetic disorder - a leading cause of renal failure - cannot be explained by inherited mutation. Instead, the disease evidently progresses by a second hit: somatic mutation superimposed on germline mutation. The source of the mutability appears to be DNA triple-helixing, as mediated by some odd genetic code, the longest polypyrimidine tract ever found in the human genome.

Original languageEnglish (US)
Pages (from-to)81-102
Number of pages22
JournalHospital Practice
Issue number3
StatePublished - Mar 15 1997

ASJC Scopus subject areas

  • General Medicine


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