Autoradiographic localization of the opiate receptor in rat brain

Candace B. Pert; Michael J. Kuhar; Solomon H. Snyder

doi:10.1016/0024-3205(75)90289-1

Autoradiographic localization of the opiate receptor in rat brain

Candace B. Pert, Michael J. Kuhar, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

293 Scopus citations

Abstract

One hour after injection of the potent opiate antagonist ³H-diprenorphine (125 μCi, 13 Ci/mmole) 75-85% of the drug is associated with opiate receptor sites. Autoradiography of fresh frozen unfixed brain has been carried out to visualize receptor distribution. Dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantia gelatinosa.

Original language	English (US)
Pages (from-to)	1849-1853
Number of pages	5
Journal	Life Sciences
Volume	16
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(75)90289-1
State	Published - Jun 15 1975

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(75)90289-1

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abstract = "One hour after injection of the potent opiate antagonist 3H-diprenorphine (125 μCi, 13 Ci/mmole) 75-85% of the drug is associated with opiate receptor sites. Autoradiography of fresh frozen unfixed brain has been carried out to visualize receptor distribution. Dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantia gelatinosa.",

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AB - One hour after injection of the potent opiate antagonist 3H-diprenorphine (125 μCi, 13 Ci/mmole) 75-85% of the drug is associated with opiate receptor sites. Autoradiography of fresh frozen unfixed brain has been carried out to visualize receptor distribution. Dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantia gelatinosa.

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Autoradiographic localization of the opiate receptor in rat brain

Abstract

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