Autoradiographic localization of the opiate receptor in rat brain

Candace B. Pert, Michael J. Kuhar, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

293 Scopus citations


One hour after injection of the potent opiate antagonist 3H-diprenorphine (125 μCi, 13 Ci/mmole) 75-85% of the drug is associated with opiate receptor sites. Autoradiography of fresh frozen unfixed brain has been carried out to visualize receptor distribution. Dense clusters of autoradiographic grains are highly localized in the caudate-putamen, locus coeruleus, zona compacta of the substantia nigra and the substantia gelatinosa.

Original languageEnglish (US)
Pages (from-to)1849-1853
Number of pages5
JournalLife Sciences
Issue number12
StatePublished - Jun 15 1975

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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