Automatic quality control using hierarchical shape analysis for cerebellum parcellation

Lianrui Zuo, Shuo Han, Aaron Carass, Sarah H. Ying, Chiadikaobi U. Onyike, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Automatic and accurate cerebellum parcellation has long been a challenging task due to the relative surface complexity and large anatomical variation of the human cerebellum. An inaccurate segmentation will inevitably bias further studies. In this paper we present an automatic approach for the quality control of cerebellum parcellation based on shape analysis in a hierarchical structure. We assume that the overall shape variation of a segmented structure comes from both population and segmentation variation. In this hierarchical structure, the higher level shape mainly captures the population variation of the human cerebellum, while the lower level shape captures both population and segmentation variation. We use a partial least squares regression to combine the lower level and higher level shape information. By compensating for population variation, we show that the estimated segmentation variation is highly correlated with the accuracy of the cerebellum parcellation results, which not only provides a confidence measurement of the cerebellum parcellation, but also gives some clues about when a segmentation software may fail in real scenarios.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationImage Processing
EditorsElsa D. Angelini, Elsa D. Angelini, Elsa D. Angelini, Bennett A. Landman
ISBN (Electronic)9781510625457
StatePublished - 2019
EventMedical Imaging 2019: Image Processing - San Diego, United States
Duration: Feb 19 2019Feb 21 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2019: Image Processing
Country/TerritoryUnited States
CitySan Diego


  • cerebellum segmentation
  • quality control
  • shape analysis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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