Autologous graft-versus-host disease induction in advanced breast cancer: Role of peripheral blood progenitor cells

E. Van Der Wall, T. Horn, E. Bright, J. L. Passos-Coehlo, S. Bond, B. Clarke, V. Altomonte, K. McIntyre, G. Vogelsang, S. J. Noga, J. M. Davis, J. Thomassen, K. V. Ohly, S. M. Lee, J. Fetting, D. K. Armstrong, N. E. Davidson, A. D. Hess, M. J. Kennedy

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The purpose of the present study was to investigate the impact of the use of peripheral blood progenitor cells (PBPCs) on the induction of autologous graft-versus-host disease (GVHD) in patients with advanced breast cancer. 14 women with stage IIIB and 36 women with stage IV breast cancer received cyclosporine (CsA) 2.5 mg kg-1 i.v. daily, d 0-28, and interferon-gamma (IFNg) 0.025 mg/m2 s.c. qod, d7-28, following PBPC-T ± bone marrow transplantation (BMT). Preceding high-dose chemotherapy consisted of cyclophosphamide 6 g/m2 and thiotepa 800 mg/m2. Histologically proven ≥grade II cutaneous GVHD was induced in 18/50 (36%) of patients and was independent of the source of haematopoietic support. In vitro studies showed that post-transplant, 76% of patients had developed auto-cytotoxicity against their own pre-transplant PHA-lymphoblasts. A significant correlation between the occurrence of GVHD ≥grade II and cytolysis was observed in the NK cell-line K562 and the T47D breast cancer cell-line. With a median follow-up of 2 1/2 years, the overall survival (OS) is 58%, the disease-free survival (DFS) 26%, both independent of the development of GVHD and similar to what has been observed in other studies on high-dose chemotherapy in advanced breast cancer. It therefore remains unclear whether the induction of autologous GVHD with the occurrence of auto-cytotoxic lymphocytes can result in an anti-tumour effect in this group of patients. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)1405-1411
Number of pages7
JournalBritish journal of cancer
Volume83
Issue number11
DOIs
StatePublished - 2000

Keywords

  • Autoreactive T-cells
  • Breast cancer
  • CLIP
  • Cyclosporine
  • MHC-class II
  • Peripheral stem ceils

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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