Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats

David A. Silverman; Noel R. Rose

doi:10.3181/00379727-138-35945

Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats

David A. Silverman
, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Spontaneous, 3-methylcholanthrene-induced, and immunologically induced thyroiditis have been investigated in the Buffalo strain of inbred rat. Circulating autoantibodies to thyroid antigen are present in each form of the disease. Antibodies to other organs, or mononuclear cell infiltrations in them were not found. The major stimulus appears to be thyroglobulin. The evidence indicates that these 3 different forms of disease have an autoimmune basis.

Original language	English (US)
Pages (from-to)	579-584
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	138
Issue number	2
DOIs	https://doi.org/10.3181/00379727-138-35945
State	Published - Nov 1971
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-138-35945

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Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats. / Silverman, David A.; Rose, Noel R.
In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.), Vol. 138, No. 2, 11.1971, p. 579-584.

Research output: Contribution to journal › Article › peer-review

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abstract = "Spontaneous, 3-methylcholanthrene-induced, and immunologically induced thyroiditis have been investigated in the Buffalo strain of inbred rat. Circulating autoantibodies to thyroid antigen are present in each form of the disease. Antibodies to other organs, or mononuclear cell infiltrations in them were not found. The major stimulus appears to be thyroglobulin. The evidence indicates that these 3 different forms of disease have an autoimmune basis.",

author = "Silverman, \{David A.\} and Rose, \{Noel R.\}",

note = "Funding Information: This work was supported in part by U.S. Public Health Service Research Grants CA 05203 and CA 02357 and NIH Training Grant A1-00130. A summary of the work was presented: Meet. Amer. Soc. Exp. Pathol., Chicago, IL, April 12-17, 1971. 11 1971 138 2 579 584 ",

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AU - Rose, Noel R.

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N2 - Spontaneous, 3-methylcholanthrene-induced, and immunologically induced thyroiditis have been investigated in the Buffalo strain of inbred rat. Circulating autoantibodies to thyroid antigen are present in each form of the disease. Antibodies to other organs, or mononuclear cell infiltrations in them were not found. The major stimulus appears to be thyroglobulin. The evidence indicates that these 3 different forms of disease have an autoimmune basis.

AB - Spontaneous, 3-methylcholanthrene-induced, and immunologically induced thyroiditis have been investigated in the Buffalo strain of inbred rat. Circulating autoantibodies to thyroid antigen are present in each form of the disease. Antibodies to other organs, or mononuclear cell infiltrations in them were not found. The major stimulus appears to be thyroglobulin. The evidence indicates that these 3 different forms of disease have an autoimmune basis.

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Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats

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