Autoimmune myocarditis

Noel R. Rose, Susan L. Hill

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


We have developed two models of myocarditis in mice. The first is produced by infection with Coxsackievirus B3; the second results from immunization with cardiac myosin. Both forms of myocarditis occur in the same genetically predisposed strains. Genetically resistant mice can be rendered susceptible to myocarditis by co-treatment with cytokines IL-1 or TNF. Moreover, the disease is inhibited by administration of an antagonist of IL-1. These models will be useful for clarifying outstanding issues related to human myocarditis or dilated cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalInternational Journal of Cardiology
Issue number2
StatePublished - May 1996
Externally publishedYes


  • Coxsackievirus B3 (CB3)
  • IL-1
  • Myocarditis
  • Myosin immunization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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