TY - JOUR
T1 - Autoantibody heritability in thyroiditis
T2 - IgG subclass contributions
AU - Outschoorn, Ingrid M.
AU - Talor, Monica V.
AU - Hoffman, William H.
AU - Rowley, Merrill J.
AU - MacKay, Ian R.
AU - Rose, Noel R.
AU - Burek, C. Lynne
N1 - Funding Information:
1Instituto de Salud Carlos III, Centro Nacional de Microbiologia, Unidad de Respuesta Inmune, Majadahonda, Madrid 28220, Spain, 2Department of Pathology, Johns Hopkins University, 720 Rutland Ave, Baltimore, MD 21205, USA, 3Johns Hopkins Center for Autoimmune Disease Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA, 4Section of Endocrinology, Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA, 5Department of Biochemistry and Molecular Biology, Monash University, 3800 VIC, Australia, and 6Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, W. Harry Feinstone, MMI-E5014, 615 N Wolfe St, Baltimore, MD 21205, USA
PY - 2011/5
Y1 - 2011/5
N2 - Using a simple screening technique called regression of offspring on mid-parent (ROMP) to examine the role of IgG subclasses in affected and unaffected siblings of children and adolescents with autoimmune thyroid disease and their parents, both total-restricted and subclass-restricted autoantibodies to thyroglobulin (Tg) were assayed quantitatively for each of the IgG subclasses. There was a significant correlation of anti-Tg titer of probands with parental titers in thyrotoxicosis (TT), (R2=0.569, p=0.001), but not in chronic lymphocytic thyroiditis. The most striking correlation was in TT patients of African-American ancestry, (R2=0.9863, p = 0.0007). Additional insight is provided by examining the contributions of the IgG subclasses individually, particularly those whose concentrations appear not to have direct influence on the total IgG titers. Thus, using small numbers of patients, and assaying the IgG subclass distributions, as well as any other immunoglobulin isotypes that are significantly altered in autoantibody assays, ROMP can be performed rapidly to ascertain which quantifiable parameters may be usefully extended to predict disease onset and progression.
AB - Using a simple screening technique called regression of offspring on mid-parent (ROMP) to examine the role of IgG subclasses in affected and unaffected siblings of children and adolescents with autoimmune thyroid disease and their parents, both total-restricted and subclass-restricted autoantibodies to thyroglobulin (Tg) were assayed quantitatively for each of the IgG subclasses. There was a significant correlation of anti-Tg titer of probands with parental titers in thyrotoxicosis (TT), (R2=0.569, p=0.001), but not in chronic lymphocytic thyroiditis. The most striking correlation was in TT patients of African-American ancestry, (R2=0.9863, p = 0.0007). Additional insight is provided by examining the contributions of the IgG subclasses individually, particularly those whose concentrations appear not to have direct influence on the total IgG titers. Thus, using small numbers of patients, and assaying the IgG subclass distributions, as well as any other immunoglobulin isotypes that are significantly altered in autoantibody assays, ROMP can be performed rapidly to ascertain which quantifiable parameters may be usefully extended to predict disease onset and progression.
KW - Autoimmune thyroid disease
KW - IgG subclass distributions
KW - ethnicity of autoantibody
KW - heritability of autoantibody
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U2 - 10.3109/08916934.2010.515275
DO - 10.3109/08916934.2010.515275
M3 - Article
C2 - 20883146
AN - SCOPUS:79953110898
SN - 0891-6934
VL - 44
SP - 195
EP - 200
JO - Autoimmunity
JF - Autoimmunity
IS - 3
ER -