Autoantibody formation in the alloimmunized red blood cell recipient. Clinical and laboratory implications

M. S. Zumberg, J. L. Procter, R. Lottenberg, C. S. Kitchens, H. G. Klein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Alloimmunization to erythrocyte antigens is a well-characterized complication in heavily transfused patients. Less well recognized, however, is the frequency of autoantibody formation in these previously alloimmunized patients. The autoantibodies are heterogeneous and of variable clinical significance. We describe the clinical history, laboratory evaluation, diagnosis, and treatment in 4 patients who developed autoantibodies in temporal association with alloantibody formation. In one case, the autoantibody found on routine screening had no clinical significance. In another case, the autoantibody made accurate blood typing and subsequent transfusion exceedingly difficult. Two patients experienced hemolysis as a consequence of the autoantibody. The management of both patients included supportive measures, while one patient required glucocorticosteroids and red blood cell transfusion. We review the published literature concerning autoimmunization in the transfused alloimmunized host. The spectrum of clinical consequences is important for the general practitioner to recognize, as these complications may occur during routine blood transfusions.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalArchives of Internal Medicine
Issue number2
StatePublished - Jan 22 2001
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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