TY - JOUR
T1 - Autoantibody biomarker opens a new gateway for cancer diagnosis
AU - Nesterova, M.
AU - Johnson, N.
AU - Cheadle, C.
AU - Cho-Chung, Y. S.
N1 - Funding Information:
We thank Drs. Susan Bates and Jeffrey Schlom (NCI, Bethesda, MD), Sridhar Mani (Albert Einstein College of Medicine, Bronx, NY), and Rishab K. Gupta (John Wayne Cancer Institute, Santa Monica, CA) for their generosity in providing us with serum samples. This research was supported by the Intramural Research Program of the National Institutes of Health, National Cancer Institute (P.I., Y.S. Cho-Chung), Bethesda, MD.
PY - 2006/4
Y1 - 2006/4
N2 - The list of cancer markers of current interest has grown considerably, but none of the markers used in clinical work is a true tumor marker. These cancer biomarkers are based on the determination of tumor antigens. Here, we report a single method of autoantibody enzyme immunoassay (EIA) screens for a spectrum of serum tumor markers. A comparison of the autoantibody-based EIA to conventional antigen EIA kits, using receiver operating characteristic (ROC) plots, showed that the autoantibody EIA can significantly enhance the sensitivity and specificity of tumor markers. The detection of serum autoantibodies for a spectrum of serum tumor markers, as demonstrated here, suggests that most, if not all, serum cancer biomarkers produce autoantibodies. A unique autoantibody biomarker screening method, as presented here, might therefore facilitate achieving the accurate and early diagnosis of cancer.
AB - The list of cancer markers of current interest has grown considerably, but none of the markers used in clinical work is a true tumor marker. These cancer biomarkers are based on the determination of tumor antigens. Here, we report a single method of autoantibody enzyme immunoassay (EIA) screens for a spectrum of serum tumor markers. A comparison of the autoantibody-based EIA to conventional antigen EIA kits, using receiver operating characteristic (ROC) plots, showed that the autoantibody EIA can significantly enhance the sensitivity and specificity of tumor markers. The detection of serum autoantibodies for a spectrum of serum tumor markers, as demonstrated here, suggests that most, if not all, serum cancer biomarkers produce autoantibodies. A unique autoantibody biomarker screening method, as presented here, might therefore facilitate achieving the accurate and early diagnosis of cancer.
KW - Autoantibody
KW - Cancer biomarker
KW - Cancer diagnosis
KW - Enzyme immunoassay
KW - Extracellular protein kinase A
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U2 - 10.1016/j.bbadis.2005.12.010
DO - 10.1016/j.bbadis.2005.12.010
M3 - Article
C2 - 16483750
AN - SCOPUS:33644772207
SN - 0925-4439
VL - 1762
SP - 398
EP - 403
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
IS - 4
ER -