TY - JOUR
T1 - Autism Spectrum Disorder Symptoms Among Children Enrolled in the Study to Explore Early Development (SEED)
AU - Wiggins, Lisa D.
AU - Levy, Susan E.
AU - Daniels, Julie
AU - Schieve, Laura
AU - Croen, Lisa A.
AU - DiGuiseppi, Carolyn
AU - Blaskey, Lisa
AU - Giarelli, Ellen
AU - Lee, Li Ching
AU - Pinto-Martin, Jennifer
AU - Reynolds, Ann
AU - Rice, Catherine
AU - Rosenberg, Cordelia Robinson
AU - Thompson, Patrick
AU - Yeargin-Allsopp, Marshalyn
AU - Young, Lisa
AU - Schendel, Diana
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York (outside the USA).
PY - 2015/10/22
Y1 - 2015/10/22
N2 - This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses.
AB - This study examined the phenotypic profiles of children aged 30–68 months in the Study to Explore Early Development (SEED). Children classified as autism spectrum disorder (ASD), developmental delay (DD) with ASD symptoms, DD without ASD symptoms, and population comparison (POP) differed significantly from each other on cognitive, adaptive, behavioral, and social functioning and the presence of parent-reported conditions. Children with ASD and DD with ASD symptoms had mild to severe ASD risk on several measures compared to children with other DD and POP who had little ASD risk across measures. We conclude that children in SEED have varying degrees of ASD impairment and associated deficits. SEED thus provides a valuable sample to explore ASD phenotypes and inform risk factor analyses.
KW - Autism
KW - Etiology
KW - Phenotype
KW - Study to Explore Early Development
KW - Symptoms
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UR - http://www.scopus.com/inward/citedby.url?scp=84941932864&partnerID=8YFLogxK
U2 - 10.1007/s10803-015-2476-8
DO - 10.1007/s10803-015-2476-8
M3 - Article
C2 - 26048040
AN - SCOPUS:84941932864
SN - 0162-3257
VL - 45
SP - 3183
EP - 3194
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 10
ER -