TY - JOUR
T1 - Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting
AU - On behalf of the Autism Working Group in Peru
AU - Jensen, Kelly
AU - Noazin, Sassan
AU - Bitterfeld, Leandra
AU - Carcelen, Andrea
AU - Vargas-Cuentas, Natalia I.
AU - Hidalgo, Daniela
AU - Valenzuela, Alejandra
AU - Roman-Gonzalez, Avid
AU - Krebs, Casey
AU - Clement, Vincent
AU - Nolan, Cody
AU - Barrientos, Franklin
AU - Mendoza, Ardi Knobel
AU - Noriega-Donis, Paola
AU - Palacios, Claudia
AU - Ramirez, Andrea
AU - Vittet, Macarena
AU - Hafeez, Emil
AU - Torres-Viso, Mariana
AU - Velarde, Myriam
AU - Moulton, Lawrence H.
AU - Powers, Michael D.
AU - Gilman, Robert H.
AU - Zimic, Mirko
AU - Cavallera, Vanessa
AU - Zavaleta, Ricardo
AU - Flores, Juan
AU - Nuñez, Dennis
AU - Dioses, Alejandro
AU - Smith, Anna
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/3
Y1 - 2021/3
N2 - Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36–99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82–0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71–0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64–0.88)) alone. This tool may enable early screening for ASD in RLS.
AB - Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36–99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82–0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71–0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64–0.88)) alone. This tool may enable early screening for ASD in RLS.
KW - ASD diagnosis
KW - Autism spectrum disorder
KW - Developmental disorder
KW - Eye tracking
KW - Gaze preference
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U2 - 10.1007/s10803-021-04878-0
DO - 10.1007/s10803-021-04878-0
M3 - Article
C2 - 33591436
AN - SCOPUS:85101141299
SN - 0162-3257
VL - 51
SP - 994
EP - 1006
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 3
ER -