TY - JOUR
T1 - Aurora kinase of the red alga Cyanidioschyzon merolae is related to both mitochondrial division and mitotic spindle formation
AU - Kato, Shoichi
AU - Imoto, Yuuta
AU - Ohnuma, Mio
AU - Matsunaga, Tomoko M.
AU - Kuroiwa, Haruko
AU - Kawano, Shigeyuki
AU - Kuroiwa, Tsuneyoshi
AU - Matsunaga, Sachihiro
PY - 2011/12
Y1 - 2011/12
N2 - In eukaryotic cells, the Aurora kinase family contributes to the successful progression of mitosis by regulating centrosome maturation, spindle formation, microtubule attachment to kinetochores, and cytokinesis. A primitive red alga, Cyanidioschyzon merolae, contains a single mitochondrion, which divides just before nuclear division. In this study, we identified a single orthologue of Aurora kinase in C. merolae, which was designated CmAUR. Analysis of the dynamics during mitosis of CmAUR fused with the green fluorescent protein showed CmAUR is localized to the mitotic spindle and polar microtubules along the mitochondrion. Interestingly, CmAUR signals were also detected in the mitochondrial division site. These results indicate Aurora kinase in C. merolae is related to mitochondrial division in addition to mitotic spindle formation.
AB - In eukaryotic cells, the Aurora kinase family contributes to the successful progression of mitosis by regulating centrosome maturation, spindle formation, microtubule attachment to kinetochores, and cytokinesis. A primitive red alga, Cyanidioschyzon merolae, contains a single mitochondrion, which divides just before nuclear division. In this study, we identified a single orthologue of Aurora kinase in C. merolae, which was designated CmAUR. Analysis of the dynamics during mitosis of CmAUR fused with the green fluorescent protein showed CmAUR is localized to the mitotic spindle and polar microtubules along the mitochondrion. Interestingly, CmAUR signals were also detected in the mitochondrial division site. These results indicate Aurora kinase in C. merolae is related to mitochondrial division in addition to mitotic spindle formation.
KW - Aurora kinase
KW - Cyanidioschyzon merolae
KW - Mitochondrial division
KW - Spindle
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U2 - 10.1508/cytologia.76.455
DO - 10.1508/cytologia.76.455
M3 - Article
AN - SCOPUS:84859728129
SN - 0011-4545
VL - 76
SP - 455
EP - 462
JO - Cytologia
JF - Cytologia
IS - 4
ER -