Augmentation in restless legs syndrome patients in Korea

Ji Ye Jeon, Hye Jin Moon, Mei Ling Song, Hochang B. Lee, Yong Won Cho

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: Augmentation has been known as the major complication of long-term dopaminergic treatment of restless legs syndrome (RLS). However, there have been no reports on the prevalence of augmentation in Korea. Thus, we aimed to assess the rate of augmentation and evaluate related factors in Korean RLS patients.Methods: Ninety-four idiopathic RLS patients who have been treated over a period of at least 6 months were enrolled. Thirty subjects were treated with a dopamine agonist only, and 64 were treated with a dopamine agonist and alpha two delta ligands. We assessed the clinical characteristics of those RLS subjects and evaluated the rate of augmentation. Augmentation was assessed using the NIH criteria for augmentation by two RLS experts independently.Results: Eleven subjects (11.7 %) were classified as having definitive or highly suggestive clinical indication of augmentation. In comparing the augmentation group with the non-augmentation group, there were no significant differences of baseline clinical characteristics. Four (13.3 %) of the dopamine agonists monotherapy group and seven (10.9 %) of the combination therapy group were categorized as augmentation. There was no significant difference in the augmentation rate between these two groups.Conclusions: We found an 11.7 % augmentation rate in Korean RLS subjects. There was no difference in the rate of RLS augmentation between the dopaminergic monotherapy group and the combined treatment group. It may be related with using a similar dosage of dopaminergic drugs.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalSleep and Breathing
Issue number2
StatePublished - Apr 15 2015
Externally publishedYes


  • Augmentation
  • Dopamine agonists
  • Prevalence
  • Restless legs syndrome

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology


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