Auditory brainstem response audiometry in tauopathy mouse model of human Alzheimer's disease

Kali Burke, Laurel A. Screven, Sergio Vicencio-Jimenez, Amanda M. Lauer

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which changes in hearing sensitivity precede cognitive decline. Despite a well-known link between dementia and hearing loss, few AD model mouse lines have hearing characterized. We screened for hearing loss using auditory brainstem responses (ABR) in young (3-4 months) and aging (9-10 months) mice with a P301S tauopathy (PS19 mice). Compared to wild types, aging PS19 mice did not show accelerated hearing loss but did show latency differences in centrally generated ABR waveform components. These results suggest that tauopathy causes mild central auditory dysfunction in the absence of overt hearing loss.

Original languageEnglish (US)
Article number071201
JournalJASA Express Letters
Volume4
Issue number7
DOIs
StatePublished - Jul 1 2024

ASJC Scopus subject areas

  • Acoustics and Ultrasonics
  • Music
  • Arts and Humanities (miscellaneous)

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