Atypical Urothelial Cells (AUC)

Güliz A. Barkan, Margaret L. Compton, Tarik M. Elsheikh, Kim A. Ely, Daniel F.I. Kurtycz, Merce Jorda, Zahra Maleki, Sachiko Minamiguchi, Hiroshi Ohtani, Eric Piaton, Bo Ping, Spasenija Savic Prince, Z. Laura Tabatabai, Christopher J. VandenBussche

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The goal for the atypical urothelial cells (AUC) category is to capture those cases worrisome for high-grade urothelial carcinoma (HGUC) but that fall short of the suspicious for HGUC (SHGUC) category. Known causes of atypia, such as polyomavirus change, treatment effect, calculi, etc., should be classified as negative for high-grade urothelial carcinoma (NHGUC). We have set forth criteria for AUCs using the cytomorphologic features: increased nuclear to cytoplasmic (N/C) ratio secondary to nuclear enlargement, abnormal nuclear chromasia and chromatin pattern, and irregularity of the chromatinic rim (nuclear membrane). We recommend restraint using the “AUC” category.

Original languageEnglish (US)
Title of host publicationThe Paris System for Reporting Urinary Cytology
Subtitle of host publicationSecond Edition
PublisherSpringer International Publishing
Pages63-83
Number of pages21
ISBN (Electronic)9783030886868
ISBN (Print)9783030886851
DOIs
StatePublished - Jan 1 2022

Keywords

  • AUC
  • Atypia
  • Atypical urothelial cells
  • Equivocal
  • Indeterminate
  • Suspicious
  • The Paris System (TPS)
  • Urothelial atypia

ASJC Scopus subject areas

  • General Medicine

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