Abstract
The goal for the atypical urothelial cells (AUC) category is to capture those cases worrisome for high-grade urothelial carcinoma (HGUC) but that fall short of the suspicious for HGUC (SHGUC) category. Known causes of atypia, such as polyomavirus change, treatment effect, calculi, etc., should be classified as negative for high-grade urothelial carcinoma (NHGUC). We have set forth criteria for AUCs using the cytomorphologic features: increased nuclear to cytoplasmic (N/C) ratio secondary to nuclear enlargement, abnormal nuclear chromasia and chromatin pattern, and irregularity of the chromatinic rim (nuclear membrane). We recommend restraint using the “AUC” category.
Original language | English (US) |
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Title of host publication | The Paris System for Reporting Urinary Cytology |
Subtitle of host publication | Second Edition |
Publisher | Springer International Publishing |
Pages | 63-83 |
Number of pages | 21 |
ISBN (Electronic) | 9783030886868 |
ISBN (Print) | 9783030886851 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- AUC
- Atypia
- Atypical urothelial cells
- Equivocal
- Indeterminate
- Suspicious
- The Paris System (TPS)
- Urothelial atypia
ASJC Scopus subject areas
- General Medicine