TY - JOUR
T1 - Atypia of undetermined significance in the Milan System for Reporting Salivary Gland Cytopathology
T2 - Cystic versus non-cystic masses
AU - Saoud, Carla
AU - Wangsiricharoen, Sintawat
AU - Kahler, Jessica
AU - Maleki, Zahra
N1 - Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2022/4
Y1 - 2022/4
N2 - The term “Atypia” has been employed to describe a wide spectrum of cytomorphologic features associated with reactive/inflammatory processes as well as those suspicious for neoplasms in cytology. Similar to other cytopathology reporting systems, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has reserved the atypical category for cytology specimens lacking quantitative and/or qualitative cytomorphologic features to be diagnosed with confidence as either non-neoplastic or neoplastic. In MSRSGC, the atypical category is associated with a risk of malignancy and recommendation for clinical management. In this review, we discuss the value of atypical diagnostic category of MSRSGC in both cystic and non-cystic salivary gland lesions by evaluating our institutional case cohort.
AB - The term “Atypia” has been employed to describe a wide spectrum of cytomorphologic features associated with reactive/inflammatory processes as well as those suspicious for neoplasms in cytology. Similar to other cytopathology reporting systems, the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has reserved the atypical category for cytology specimens lacking quantitative and/or qualitative cytomorphologic features to be diagnosed with confidence as either non-neoplastic or neoplastic. In MSRSGC, the atypical category is associated with a risk of malignancy and recommendation for clinical management. In this review, we discuss the value of atypical diagnostic category of MSRSGC in both cystic and non-cystic salivary gland lesions by evaluating our institutional case cohort.
KW - Milan system for reporting salivary gland cytopathology
KW - atypia of undetermined significance
KW - cystic versus non-cystic
KW - fine needle aspiration
KW - salivary gland cytology
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U2 - 10.1002/dc.24913
DO - 10.1002/dc.24913
M3 - Article
C2 - 34989152
AN - SCOPUS:85122288687
SN - 8755-1039
VL - 50
SP - 154
EP - 161
JO - Diagnostic cytopathology
JF - Diagnostic cytopathology
IS - 4
ER -