Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation

Madeliene Stump; Harpinder Dhinsa; Jennifer Powers; Mary Stone

doi:10.1111/pde.14876

Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation

Madeliene Stump, Harpinder Dhinsa, Jennifer Powers, Mary Stone

Research output: Contribution to journal › Article › peer-review

Abstract

Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.

Original language	English (US)
Pages (from-to)	145-146
Number of pages	2
Journal	Pediatric Dermatology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1111/pde.14876
State	Published - Jan 1 2022
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Dermatology

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10.1111/pde.14876

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abstract = "Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.",

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AU - Powers, Jennifer

AU - Stone, Mary

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AB - Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.

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Attenuation of actinic prurigo eruptions with Polypodium leucotomos supplementation

Abstract

ASJC Scopus subject areas

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