Attenuation correction in cardiac PET/CT with three different CT protocols: A comparison with conventional PET

Michael Souvatzoglou, Frank Bengel, Raymonde Busch, Coletta Kruschke, Helga Fernolendt, Denise Lee, Markus Schwaiger, Stephan G. Nekolla

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Purpose: CT-based attenuation correction may influence cardiac PET owing to its higher susceptibility to misalignment compared with conventional 68Ge transmission scans. The aims of this study were to evaluate whether CT attenuation correction leads to changes in tracer distribution compared with conventional cardiac PET and to determine a suitable CT protocol. Methods: A total of 27 patients underwent PET/CT and subsequently a PET scan. Twenty patients received a low-dose CT (LDCT group; 120 kV, 26 mA, 8-s scan time), seven patients a slow CT (SCT group; 120 kV, 99 mA, 46-s scan time) and ten patients an ultra-low-dose CT (ULDCT group; 80 kV, 13 mA, 5-s scan time) as the transmission scan in PET/CT. Polar maps were divided into 17 segments and regression analysis was computed in every scan pair (CT attenuation corrected-68Ge attenuation corrected). Correlation coefficient (r), the slope (s) and the offset (os) of the regression line were determined. Visual assessment of misalignment between the transmission and emission data was performed. The effective dose of the different transmission scans was calculated. Results: Overall, there was a moderate correlation between the mean values measured in all segments on PET/CT and on PET when using LDCT (r=0.78, p

Original languageEnglish (US)
Pages (from-to)1991-2000
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number12
StatePublished - Dec 2007
Externally publishedYes


  • Attenuation correction
  • Breathing artefacts
  • Cardiac computed tomography
  • Combined PET/CT
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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