Attenuated fever response in mice lacking TRPV1

Tohko Iida, Isao Shimizu, Michele L. Nealen, Ashley Campbell, Michael Caterina

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrahypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1-/- mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35°C) or decreased (4°C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1-/- mice. Despite this finding, we detected no significant differences between TRPV1-/- and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV1 participates in the generation of polyphasic fever, perhaps at sites outside the brain.

Original languageEnglish (US)
Pages (from-to)28-33
Number of pages6
JournalNeuroscience Letters
Issue number1
StatePublished - Apr 11 2005


  • Capsaicin
  • Fever
  • Lipopolysaccharide
  • TRPV1
  • Thermoregulation
  • Vanilloid

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Attenuated fever response in mice lacking TRPV1'. Together they form a unique fingerprint.

Cite this