ATP synthase: structure-function relationships

Philip J. Thomas; Mario Bianchet; David N. Garboczi; Joanne Hullihen; L. Mario Amzel; Peter L Pedersen

ATP synthase: structure-function relationships

Philip J. Thomas, Mario Bianchet, David N. Garboczi, Joanne Hullihen, L. Mario Amzel, Peter L Pedersen

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Recent work has focused on obtaining a better understanding of the three-dimensional structural relationships between the α and β subunits of the F₁ moiety and the location of nucleotide binding domains within these subunits. Four types of approach are currently being pursued: X-ray crystallographic, chemical, molecular biological and biochemical. Here we briefly review some of the major conclusions of these studies, and point out some of the problems that must be resolved before an adequate model that relates structure to function in the ATP synthase molecule can be formulated.

Original language	English (US)
Pages (from-to)	228-231
Number of pages	4
Journal	Biochimica et Biophysica Acta - Bioenergetics
Volume	1101
Issue number	2
State	Published - Jul 17 1992

Keywords

ATP synthase
ATP synthesis
ATPase
F

ASJC Scopus subject areas

Biophysics

Cite this

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AU - Bianchet, Mario

AU - Garboczi, David N.

AU - Hullihen, Joanne

AU - Amzel, L. Mario

AU - Pedersen, Peter L

PY - 1992/7/17

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AB - Recent work has focused on obtaining a better understanding of the three-dimensional structural relationships between the α and β subunits of the F1 moiety and the location of nucleotide binding domains within these subunits. Four types of approach are currently being pursued: X-ray crystallographic, chemical, molecular biological and biochemical. Here we briefly review some of the major conclusions of these studies, and point out some of the problems that must be resolved before an adequate model that relates structure to function in the ATP synthase molecule can be formulated.

KW - ATP synthase

KW - ATP synthesis

KW - ATPase

KW - F

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ATP synthase: structure-function relationships

Abstract

Keywords

ASJC Scopus subject areas

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