ATM serine/threonine kinase and its role in pancreatic risk

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Next-generation sequencing has led to the recent discovery of several novel pancreatic cancer susceptibility genes. These genes include ataxia telangiectasia mutated (ATM), a serine/threonine kinase that is an integral component of DNA repair. Pathogenic germline ATM variants are frequently identified in patients with pancreatic ductal adenocarcinoma (PDAC) with and without a family history of the disease. Loss of ATM is also a frequent somatic event in the development of PDAC. These discoveries have advanced our understanding of the genetic basis of pancreatic cancer risk and will impact patient care through appropriate patient-risk stratification, personalized screening and early detection efforts, and, for some, targeted therapy.

Original languageEnglish (US)
Article number108
Issue number1
StatePublished - Jan 2020


  • ATM
  • Genetics
  • Pancreatic cancer
  • Pancreatic ductal adenocarcinoma
  • Predisposition

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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