TY - JOUR
T1 - Atherosclerosis in apoE knockout mice infected with multiple pathogens
AU - Burnett, Mary Susan
AU - Gaydos, Charlotte A.
AU - Madico, Guillermo E.
AU - Glad, Stephanie M.
AU - Paigen, Beverly
AU - Quinn, Thomas C.
AU - Epstein, Stephen E.
N1 - Funding Information:
Financial support: internal funds from the Cardiovascular Research Institute, Washington Hospital Center; Johns Hopkins University; National Institute of Allergy and Infectious Diseases, National Institutes of Health; and Jackson Laboratory.
PY - 2001/1/15
Y1 - 2001/1/15
N2 - Cytomegalovirus (CMV) and Chlamydia pneumoniae (CP) possibly contribute to atherosclerosis. Murine CMV (MCMV) and CP increase lesion size in apoE knockout mice. In this study, apoE knockout mice were infected with MCMV and CP to determine whether infection with multiple pathogens increases lesion size to a greater extent than either pathogen alone and whether infection with MCMV changes serum cytokine levels in a manner that could increase lesion development. One group of mice received MCMV at 2 weeks of age, followed by 2 doses of CP at 6 and 8 weeks of age. Additional groups received only MCMV or CP. Animals were killed at 16 weeks of age to determine lesion area. Infection with MCMV alone, CP alone, and both MCMV and CP increased lesion size 84% (P < .001), 70% (P <.0001), and 45% (P < .01), respectively. The MCMV-induced increase in circulating levels of interferon-γ may have contributed to this increase.
AB - Cytomegalovirus (CMV) and Chlamydia pneumoniae (CP) possibly contribute to atherosclerosis. Murine CMV (MCMV) and CP increase lesion size in apoE knockout mice. In this study, apoE knockout mice were infected with MCMV and CP to determine whether infection with multiple pathogens increases lesion size to a greater extent than either pathogen alone and whether infection with MCMV changes serum cytokine levels in a manner that could increase lesion development. One group of mice received MCMV at 2 weeks of age, followed by 2 doses of CP at 6 and 8 weeks of age. Additional groups received only MCMV or CP. Animals were killed at 16 weeks of age to determine lesion area. Infection with MCMV alone, CP alone, and both MCMV and CP increased lesion size 84% (P < .001), 70% (P <.0001), and 45% (P < .01), respectively. The MCMV-induced increase in circulating levels of interferon-γ may have contributed to this increase.
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U2 - 10.1086/317938
DO - 10.1086/317938
M3 - Article
C2 - 11120928
AN - SCOPUS:0035863436
SN - 0022-1899
VL - 183
SP - 226
EP - 231
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -