@article{08fae9d8f1244e828e9c310ac3a93e29,
title = "Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition",
abstract = "Hinge et al. show that mitochondria are permanently remodeled after HSC division despite re-entry into quiescence. HSCs keep dysfunctional mitochondria through asymmetric segregation during mitosis, which does not prevent reversible HSC quiescence and cell cycle progression but drives their functional decline via asynchrony in the cell cycle and biosynthetic gene expression.",
author = "Ashwini Hinge and Jingyi He and James Bartram and Jose Javier and Juying Xu and Ellen Fjellman and Hiromi Sesaki and Tingyu Li and Jie Yu and Mark Wunderlich and James Mulloy and Matthew Kofron and Nathan Salomonis and Grimes, {H. Leighton} and Filippi, {Marie Dominique}",
note = "Funding Information: We thank Drs. Jose Cancelas, Damien Reynaud, and Daniel Lucas (Division of Experimental Hematology and Cancer Biology [CCHMC]) for important comments on the manuscript. We thank Dr. David Muench for technical assistance. We thank the mouse core staff, Jeff Bailey and Victoria Summey, for bone marrow transplants and the flow cytometry core for assistance with cell sorting at Cincinnati Children{\textquoteright}s Hospital Medical Center. We thank Olena Kolesnichenko for careful reading of the manuscript. The work was supported by NIH ( DK102890 and HL090676 to M.-D.F.), a Pilot Innovative Project ( CCHMC to M.-D.F.), an American Society of Hematology bridge award (to M.-D.F.), R01 HL122661 and R21 AI35595 (to H.L.G.), and the Evans MDS Foundation (to H.L.G.). Funding Information: We thank Drs. Jose Cancelas, Damien Reynaud, and Daniel Lucas (Division of Experimental Hematology and Cancer Biology [CCHMC]) for important comments on the manuscript. We thank Dr. David Muench for technical assistance. We thank the mouse core staff, Jeff Bailey and Victoria Summey, for bone marrow transplants and the flow cytometry core for assistance with cell sorting at Cincinnati Children's Hospital Medical Center. We thank Olena Kolesnichenko for careful reading of the manuscript. The work was supported by NIH (DK102890 and HL090676 to M.-D.F.), a Pilot Innovative Project (CCHMC to M.-D.F.), an American Society of Hematology bridge award (to M.-D.F.), R01 HL122661 and R21 AI35595 (to H.L.G.), and the Evans MDS Foundation (to H.L.G.). Conceptualization, A.H. J.H. J.B. N.S. H.L.G. and M.-D.F.; Methodology, M.W. J.M. and H.S.; Investigation, A.H. J.H. J.B. J.J. J.X. E.F. and M.W.; Formal Analysis, N.S. H.L.G. and M.-D.F.; Writing ? Original Draft, A.H. J.H. J.B. and M.-D.F.; Writing ? Review & Editing, J.H. N.S. H.L.G. and M.-D.F.; Funding Acquisition: H.L.G. and M.-D.F.; Resources, M.W. J.M. H.S. T.L. and J.Y.; Supervision, M.-D.F. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = mar,
day = "5",
doi = "10.1016/j.stem.2020.01.016",
language = "English (US)",
volume = "26",
pages = "420--430.e6",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "3",
}