@article{7c1bdcf626b7458f80ed7cd829b392ac,
title = "Asymmetrical cerebrovascular response to right and left hemisphere cortical suction lesions in the rat",
abstract = "We have previously demonstrated that focal lesions of the right but not left cerebral cortex in the rat produce hyperactivity and depletions of norepinephrine. To assess the cerebrovascular response to suction lesions, postoperative rats were infused intravenously with [14C]inulin. The brain inulin concentration in the right lesion group was significantly higher than control (no surgery) or left lesion groups in all cortical quadrants, but most prominently in the quadrant posterior and contralateral to the lesion site.",
keywords = "asymmetry, cerebral cortex, cortical lesion, rat cerebral vasculature",
author = "Margolis, {Russell L.} and Black, {Ronald S.} and Robinson, {Robert G.}",
note = "Funding Information: which follows right hemisphere suction lesions must be the result of increased inulin content within the cerebral vasculature or/and increased extravasation of inulin from cerebral blood vessels. Although the data from this study do not allow us to determine which of these processes is most important in this phenomenon, we are currently examining the distribution of differently sized molecules to determine if changes in the blood-brain barrier have occurred. At the present time we can only report this lateralized response to cortical injury as an interesting and potentially important phenomenon which will require further investigation. There are, however, several significant implications of this study. First, the asymmetry described in this study parallels the behavioral and biochemical asymmetries we have previously de-scribedS,m, l~. The direction of cause and effect, if such a relationship exists, awaits elucidation. Second, our results call into question the frequent assumption that, for experimental purposes, the vascu- lature of the left and right cerebral cortices may be considered identical. Finally, the hemisphere of cerebral damage in patients with strokes has an importam influence o11 the development ~f mood disorderskL Perhaps this laterality in the response of the cerebral vasculature to injury may have important effects on the behavioral and neurophysiological changes accompanying stroke, 1 Amtrop, O., Estimation of capillary permeability of inulin, sucrose and mannitol in rat brain cortex, Acta physiol. scand., 110 (1980) 337-342. 2 Capra, N. F., Vallenas, M. and Halsey, J. H., Adrenergic cerebrovascular nerves: effect of middle cerebral artery oc-clusion on the catecholamine fluorescence of sympathetic cerebrovascular nerves in cats, Exp. Neurol., 57 (1977) 409-418. 3 Hartman, B. K., Zide, D. and Udenfriend, S., The use of dopamine-fl-hydroxylase as a marker for the central nor-adrenergic nervous system in rat brain, Proc. nat. Acad. Sci. U.S.A., 69 (1972) 2722-2726. 4 Heffner, T. G., Hartman, J. A. and Seiden, L. A., A rapid method for the regional dissection of the rat brain, Pharma-col. Biochem. Behav., 13 (1980) 453-456. 5 Heistad, D. D., Summary of symposium on cerebral blood flow: effect of nerves and neurotransmitters, J. cereb. Blood Flow Metab., 1 (1981) 447-450. 6 Kubos, K. L., Moran, T. H., Saad, K. M. and Robinson, R. G., Focal cortical DSP-4 injections induce lateralized hy-peractivity in the rat, Pharmacol. Biochem. Behav., in press. 7 Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J., Protein measurement with the folin phenol reagent, J. biol. Chem., 193 (1951) 265-275. 8 Pearlson, G. D. and Robinson, R. G., Suction lesions of the frontal cerebral cortex in the rat induce asymmetrical be-havioral and catecholaminergic responses, Brain Research, 218 (1981) 233-242. 9 Preskorn, S. H., Hartman, B. K., Raichle, M. E., Swan-son, L. W. and Clark, H. B., Central adrenergic regulation of cerebral microvascular permeability and blood flow: This work was supported in part by the Dennison Scholarship from the Johns Hopkins University School of Medicine (R.L.M. and R.S.B.); the Student Fellowship Award from the American Heart Association (R.L.M. and R.S,B.) and the McAlpin Award from Johns Hopkins University School of Medicine (R.S.B.) and NIH grants Research Scientist Development Award (R.G.R.) MH 00163, NS 15178, NS 18622 and Biomedical Research Support Grant 2507 RR05 378-21. Paula Bolduc did the typing and Curtis H. Smith did the graphic work and provided technical assistance.",
year = "1984",
month = aug,
day = "13",
doi = "10.1016/0006-8993(84)91074-6",
language = "English (US)",
volume = "308",
pages = "337--340",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}