TY - JOUR
T1 - Asthma, type 1 and type 2 diabetes mellitus, and inflammatory bowel disease amongst South Asian immigrants to Canada and their children
T2 - A population-based cohort study
AU - Benchimol, Eric I.
AU - Manuel, Douglas G.
AU - To, Teresa
AU - Mack, David R.
AU - Nguyen, Geoffrey C.
AU - Gommerman, Jennifer L.
AU - Croitoru, Kenneth
AU - Mojaverian, Nassim
AU - Wang, Xuesong
AU - Quach, Pauline
AU - Guttmann, Astrid
N1 - Funding Information:
This work was made possible with the support of the Institute for Clinical Evaluative Sciences (ICES) which receives funding from the Ontario MOHLTC as well as a grant from the University of Toronto, Faculty of Medicine. The Ontario portion of Canadian immigration data was provided to ICES by Citizenship and Immigration Canada. The results and conclusions are those of the authors; no official endorsement by the Ontario MOHLTC or Citizenship and Immigration Canada should be inferred. Eric Benchimol is supported by a Career Development Award from the Canadian Child Health Clinician Scientist Program. Astrid Guttmann is supported by a CIHR Chair in Reproductive and Child Health Services and Policy Research. Geoffrey Nguyen is a recipient of New Investigator Awards from CIHR and the Crohn’s and Colitis Foundation of Canada. Jennifer Gommerman is supported by the CIHR, the Kidney Foundation of Canada and the MS Society of Canada.
Publisher Copyright:
© 2015 Benchimol et al.
PY - 2015/4/7
Y1 - 2015/4/7
N2 - BACKGROUND: There is a high and rising rate of immune-mediated diseases in the Western world. Immigrants from South Asia have been reported to be at higher risk upon arrival to the West. We determined the risk of immune-mediated diseases in South Asian and other immigrants to Ontario, Canada, and their Ontario-born children. METHODS: Population-based cohorts of patients with asthma, type 1 diabetes (T1DM), type 2 diabetes (T2DM), and inflammatory bowel disease (IBD) were derived from health administrative data. We determined the standardized incidence, and the adjusted risk of these diseases in immigrants from South Asia, immigrants from other regions, compared with non-immigrant residents of Ontario. The risk of these diseases in the Ontario-born children of immigrants were compared to the children of non-immigrants. RESULTS: Compared to non-immigrants, adults from South Asia had higher risk of asthma (IRR 1.56, 95%CI 1.51-1.61) and T2DM (IRR 2.59, 95%CI 2.53-2.65). Adults from South Asia had lower incidence of IBD than non-immigrants (IRR 0.32, 95%CI 0.22-0.49), as did immigrants from other regions (IRR 0.29, 95%CI 0.20-0.42). Compared to non-immigrant children, the incidence of asthma (IRR 0.66, 95%CI 0.62-0.71) and IBD (IRR 0.47, 95%CI 0.33-0.67) was low amongst immigrant children from South Asia. However, the risk in Ontario-born children of South Asian immigrants relative to the children of non-immigrants was higher for asthma (IRR 1.75, 95%CI 1.69-1.81) and less attenuated for IBD (IRR 0.90, 95%CI 0.65-1.22). CONCLUSION: Early-life environmental exposures may trigger a genetic predisposition to the development of asthma and IBD in South Asian immigrants and their Canada-born children.
AB - BACKGROUND: There is a high and rising rate of immune-mediated diseases in the Western world. Immigrants from South Asia have been reported to be at higher risk upon arrival to the West. We determined the risk of immune-mediated diseases in South Asian and other immigrants to Ontario, Canada, and their Ontario-born children. METHODS: Population-based cohorts of patients with asthma, type 1 diabetes (T1DM), type 2 diabetes (T2DM), and inflammatory bowel disease (IBD) were derived from health administrative data. We determined the standardized incidence, and the adjusted risk of these diseases in immigrants from South Asia, immigrants from other regions, compared with non-immigrant residents of Ontario. The risk of these diseases in the Ontario-born children of immigrants were compared to the children of non-immigrants. RESULTS: Compared to non-immigrants, adults from South Asia had higher risk of asthma (IRR 1.56, 95%CI 1.51-1.61) and T2DM (IRR 2.59, 95%CI 2.53-2.65). Adults from South Asia had lower incidence of IBD than non-immigrants (IRR 0.32, 95%CI 0.22-0.49), as did immigrants from other regions (IRR 0.29, 95%CI 0.20-0.42). Compared to non-immigrant children, the incidence of asthma (IRR 0.66, 95%CI 0.62-0.71) and IBD (IRR 0.47, 95%CI 0.33-0.67) was low amongst immigrant children from South Asia. However, the risk in Ontario-born children of South Asian immigrants relative to the children of non-immigrants was higher for asthma (IRR 1.75, 95%CI 1.69-1.81) and less attenuated for IBD (IRR 0.90, 95%CI 0.65-1.22). CONCLUSION: Early-life environmental exposures may trigger a genetic predisposition to the development of asthma and IBD in South Asian immigrants and their Canada-born children.
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U2 - 10.1371/journal.pone.0123599
DO - 10.1371/journal.pone.0123599
M3 - Article
C2 - 25849480
AN - SCOPUS:84927563680
SN - 1932-6203
VL - 10
JO - PloS one
JF - PloS one
IS - 4
M1 - e0123599
ER -