TY - JOUR
T1 - Associations of SARS-CoV-2 antibodies with birth outcomes
T2 - Results from three urban birth cohorts in the NIH environmental influences on child health outcomes program
AU - Environmental influences on Child Health Outcomes
AU - Trasande, Leonardo
AU - Comstock, Sarah S.
AU - Herbstman, Julie B.
AU - Margolis, Amy
AU - Alcedo, Garry
AU - Afanasyeva, Yelena
AU - Yu, Keunhyung
AU - Lee, William
AU - Lawrence, David A.
AU - Smith, P. B.
AU - Newby, K. L.
AU - Jacobson, L. P.
AU - Catellier, D. J.
AU - Gershon, R.
AU - Cella, D.
AU - Gern, J.
AU - Miller, R.
AU - Kerver, J.
AU - Barone, C.
AU - McKane, P.
AU - Paneth, N.
AU - Elliott, M.
N1 - Publisher Copyright:
© 2023 Trasande et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023/11
Y1 - 2023/11
N2 - Studies suggest perinatal infection with SARS-CoV-2 can induce adverse birth outcomes, but studies published to date have substantial limitations. We therefore conducted an observational study of 211 births occurring between January 2020-September 2021 in three urban cohorts participating in the Environmental Influences on Child Health Outcomes Program. Serology was assessed for IgG, IgM and IgA antibodies to nucleocapsid, S1 spike, S2 spike, and receptor-binding domain. There were no differences in gestational age (GA), birth weight, preterm birth (PTB) or low birth weight (LBW) among seropositive mothers. However, the few (n = 9) IgM seropositive mothers had children with lower BW (434g, 95% CI: 116–752), BW Z score-for-GA (0.73 SD, 95% CI 0.10–1.36) and were more likely to deliver preterm (OR 8.75, 95% CI 1.22–62.4). Though there are limits to interpretation, the data support efforts to prevent SARS-CoV-2 infections in pregnancy.
AB - Studies suggest perinatal infection with SARS-CoV-2 can induce adverse birth outcomes, but studies published to date have substantial limitations. We therefore conducted an observational study of 211 births occurring between January 2020-September 2021 in three urban cohorts participating in the Environmental Influences on Child Health Outcomes Program. Serology was assessed for IgG, IgM and IgA antibodies to nucleocapsid, S1 spike, S2 spike, and receptor-binding domain. There were no differences in gestational age (GA), birth weight, preterm birth (PTB) or low birth weight (LBW) among seropositive mothers. However, the few (n = 9) IgM seropositive mothers had children with lower BW (434g, 95% CI: 116–752), BW Z score-for-GA (0.73 SD, 95% CI 0.10–1.36) and were more likely to deliver preterm (OR 8.75, 95% CI 1.22–62.4). Though there are limits to interpretation, the data support efforts to prevent SARS-CoV-2 infections in pregnancy.
UR - https://www.scopus.com/pages/publications/85177888218
UR - https://www.scopus.com/pages/publications/85177888218#tab=citedBy
U2 - 10.1371/journal.pone.0293652
DO - 10.1371/journal.pone.0293652
M3 - Article
C2 - 37992059
AN - SCOPUS:85177888218
SN - 1932-6203
VL - 18
JO - PloS one
JF - PloS one
IS - 11 November
M1 - e0293652
ER -