Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence

Farah Qureshi; Izzuddin M. Aris; Sheryl L. Rifas-Shiman; Wei Perng; Emily Oken; Janet Rich-Edwards; Andres Cardenas; Andrea A. Baccarelli; Michelle Bosquet Enlow; Mandy B. Belfort; Henning Tiemeier

doi:10.1111/ijpo.12977

Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence

Farah Qureshi, Izzuddin M. Aris, Sheryl L. Rifas-Shiman, Wei Perng, Emily Oken, Janet Rich-Edwards, Andres Cardenas, Andrea A. Baccarelli, Michelle Bosquet Enlow, Mandy B. Belfort, Henning Tiemeier

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life. Methods: Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m²) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure. Results: LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (β = 0.99, 95% CI = 0.16, 1.82; p_{sex interaction} = 0.015) and an earlier age of rebound for both males and females (β_combined = −5.26, 95% CI = −9.44, −1.08). Conclusion: LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease.

Original language	English (US)
Article number	e12977
Journal	Pediatric Obesity
Volume	18
Issue number	1
DOIs	https://doi.org/10.1111/ijpo.12977
State	Published - Jan 2023

Keywords

BMI peak
BMI rebound
adiposity
body mass index
developmental origins of disease
telomeres

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health Policy
Nutrition and Dietetics
Pediatrics, Perinatology, and Child Health

Access to Document

10.1111/ijpo.12977

Cite this

@article{371e7c85e1534f93aecd01a9e79e6eba,

title = "Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence",

abstract = "Objective: Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life. Methods: Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m2) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure. Results: LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (β = 0.99, 95% CI = 0.16, 1.82; psex interaction = 0.015) and an earlier age of rebound for both males and females (βcombined = −5.26, 95% CI = −9.44, −1.08). Conclusion: LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease.",

keywords = "BMI peak, BMI rebound, adiposity, body mass index, developmental origins of disease, telomeres",

author = "Farah Qureshi and Aris, {Izzuddin M.} and Rifas-Shiman, {Sheryl L.} and Wei Perng and Emily Oken and Janet Rich-Edwards and Andres Cardenas and Baccarelli, {Andrea A.} and Enlow, {Michelle Bosquet} and Belfort, {Mandy B.} and Henning Tiemeier",

note = "Funding Information: This research uses data from Project Viva, which is supported by the National Institutes of Health (NIH; R01HD034568 and UH3OD023286). Farah Qureshi was supported by the NIH (T32 CA 009001) and a pilot award from the Telomere Research Network at Tulane University, which is funded by the National Institute of Aging and the National Institute of Environmental Health Sciences at the NIH. Andres Cardenas was supported by the NIH (R01ES031259 and R03AG067064); as was Michelle Bosquet Enlow (R01HD082078). The content of this manuscript is the sole responsibility of the authors. Publisher Copyright: {\textcopyright} 2022 World Obesity Federation.",

year = "2023",

month = jan,

doi = "10.1111/ijpo.12977",

language = "English (US)",

volume = "18",

journal = "Pediatric Obesity",

issn = "2047-6302",

publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",

number = "1",

}

TY - JOUR

T1 - Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence

AU - Qureshi, Farah

AU - Aris, Izzuddin M.

AU - Rifas-Shiman, Sheryl L.

AU - Perng, Wei

AU - Oken, Emily

AU - Rich-Edwards, Janet

AU - Cardenas, Andres

AU - Baccarelli, Andrea A.

AU - Enlow, Michelle Bosquet

AU - Belfort, Mandy B.

AU - Tiemeier, Henning

N1 - Funding Information: This research uses data from Project Viva, which is supported by the National Institutes of Health (NIH; R01HD034568 and UH3OD023286). Farah Qureshi was supported by the NIH (T32 CA 009001) and a pilot award from the Telomere Research Network at Tulane University, which is funded by the National Institute of Aging and the National Institute of Environmental Health Sciences at the NIH. Andres Cardenas was supported by the NIH (R01ES031259 and R03AG067064); as was Michelle Bosquet Enlow (R01HD082078). The content of this manuscript is the sole responsibility of the authors. Publisher Copyright: © 2022 World Obesity Federation.

PY - 2023/1

Y1 - 2023/1

N2 - Objective: Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life. Methods: Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m2) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure. Results: LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (β = 0.99, 95% CI = 0.16, 1.82; psex interaction = 0.015) and an earlier age of rebound for both males and females (βcombined = −5.26, 95% CI = −9.44, −1.08). Conclusion: LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease.

AB - Objective: Leukocyte telomere length (LTL) may be a biomarker for chronic disease susceptibility, but no work has tested this hypothesis directly. Our study investigated associations of LTL at birth with markers of adiposity growth that are linked with cardiometabolic health later in life. Methods: Participants were 375 children in Project Viva (48% female, 71% White). Body mass index (BMI) trajectories from birth to 18 years were tracked using repeated measures of BMI collected in physical examinations and via medical records, then used to predict age (months) and magnitude (kg/m2) of BMI peak and rebound. LTL was measured from cord blood via duplex quantitative PCR. A binary variable indicating LTL shorter than the reference population average was the primary exposure. Results: LTL was unrelated to BMI at peak or rebound, but associations were apparent with the timing of BMI growth milestones. Short LTL was related to a later age of peak for females (β = 0.99, 95% CI = 0.16, 1.82; psex interaction = 0.015) and an earlier age of rebound for both males and females (βcombined = −5.26, 95% CI = −9.44, −1.08). Conclusion: LTL at birth may be an early biomarker of altered adiposity growth. Newborn telomere biology may shed new insight into the developmental origins of health and disease.

KW - BMI peak

KW - BMI rebound

KW - adiposity

KW - body mass index

KW - developmental origins of disease

KW - telomeres

UR - http://www.scopus.com/inward/record.url?scp=85137491933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137491933&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12977

DO - 10.1111/ijpo.12977

M3 - Article

C2 - 36085441

AN - SCOPUS:85137491933

SN - 2047-6302

VL - 18

JO - Pediatric Obesity

JF - Pediatric Obesity

IS - 1

M1 - e12977

ER -

Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this