TY - JOUR
T1 - Associations of aortic Windkessel function with age, gender and cardiovascular risk factors
AU - Nagai, Yoji
AU - Helwegen, Jeroen
AU - Fleg, Jerome L.
AU - Beemer, Mary K.
AU - Earley, Christopher J.
AU - Metter, E. Jeffrey
PY - 2001
Y1 - 2001
N2 - Aortic Windkessel function is thought to represent a potential cardiovascular risk factor. As an indicator for the function, we have recently introduced the decay index (DI). DI is the coefficient of an exponential function applied to the postpeak portion of internal carotid artery Doppler waveform, and is inversely associated with the function. This study compares DI with age, gender and traditional cardiovascular risk factors in 220 apparently healthy volunteers (59 ± 16 years). DI increased linearly with age (r = 0.51, p < 0.001), and was higher in women than in men at all ages (p < 0.001). Also, DI was positively associated with systolic blood pressure (β = 0.17, p < 0.01) and diabetic medication (β = 0.14, p < 0.05), independent of age (β = 0.49, p < 0.0001), gender (β = 0.27, p < 0.0001) and other traditional cardiovascular risk factors (model r2 = 0.36). Based on the present results, the Windkessel function as assessed by DI declines with age and is lower in women. However, the associations with cardiovascular risk factors need to be established on a larger sample at higher cardiovascular risk.
AB - Aortic Windkessel function is thought to represent a potential cardiovascular risk factor. As an indicator for the function, we have recently introduced the decay index (DI). DI is the coefficient of an exponential function applied to the postpeak portion of internal carotid artery Doppler waveform, and is inversely associated with the function. This study compares DI with age, gender and traditional cardiovascular risk factors in 220 apparently healthy volunteers (59 ± 16 years). DI increased linearly with age (r = 0.51, p < 0.001), and was higher in women than in men at all ages (p < 0.001). Also, DI was positively associated with systolic blood pressure (β = 0.17, p < 0.01) and diabetic medication (β = 0.14, p < 0.05), independent of age (β = 0.49, p < 0.0001), gender (β = 0.27, p < 0.0001) and other traditional cardiovascular risk factors (model r2 = 0.36). Based on the present results, the Windkessel function as assessed by DI declines with age and is lower in women. However, the associations with cardiovascular risk factors need to be established on a larger sample at higher cardiovascular risk.
KW - Age
KW - Gender
KW - Risk factors
KW - Ultrasound
KW - Windkessel function
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UR - http://www.scopus.com/inward/citedby.url?scp=0034814903&partnerID=8YFLogxK
U2 - 10.1016/S0301-5629(01)00445-8
DO - 10.1016/S0301-5629(01)00445-8
M3 - Article
C2 - 11597361
AN - SCOPUS:0034814903
SN - 0301-5629
VL - 27
SP - 1207
EP - 1210
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 9
ER -