Associations between Cloninger's temperament dimensions and acute tobacco withdrawal

Adam M. Leventhal, Andrew J. Waters, Susan Boyd, Eric T. Moolchan, Stephen J. Heishman, Caryn Lerman, Wallace B. Pickworth

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


This study examined associations between three temperament dimensions measured by the Temperament and Character Inventory-125 [Cloninger, C.R. (1992). The Temperament and Character Inventory-125 (TCI-125; Version 1.)] and tobacco abstinence effects. Smokers (N = 203, ≥ 15 cigarettes/day) attended two laboratory sessions, one following 12 h of abstinence and the other following ad libitum smoking (order counterbalanced). Participants completed measures of withdrawal symptoms, cigarette urges, and affect. Smokers high in Novelty Seeking reported greater abstinence-induced increases in several nicotine withdrawal symptoms, negative affect, and cigarette craving. Smokers high in Harm Avoidance reported greater abstinence-induced increases in negative affect and urges to smoke to relieve distress. Reward Dependence was not associated with abstinence effects. Novelty Seeking and Harm Avoidance showed independent predictive associations with negative affect and urges, and their associations with abstinence effects persisted when controlling for FTND scores. Smokers with different temperaments display different patterns of acute tobacco withdrawal, and may benefit from treatments matched to their particular abstinence profile.

Original languageEnglish (US)
Pages (from-to)2976-2989
Number of pages14
JournalAddictive Behaviors
Issue number12
StatePublished - Dec 2007
Externally publishedYes


  • Harm Avoidance
  • Nicotine withdrawal
  • Novelty Seeking
  • Reward Dependence
  • Temperament
  • Temperament and Character Inventory

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health


Dive into the research topics of 'Associations between Cloninger's temperament dimensions and acute tobacco withdrawal'. Together they form a unique fingerprint.

Cite this