Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Michelle C. Johansen, Wendy Wang, Michael J. Zhang, Alvaro Alonso, Dean F. Wong, Rebecca F. Gottesman, Lin Y. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Alzheimer's Disease
Volume86
Issue number1
DOIs
StatePublished - 2022

Keywords

  • Arrhythmias
  • atrial fibrillation
  • cognitive impairment
  • imaging

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Clinical Psychology
  • General Neuroscience

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