Association study of X chromosome SNPs in attempted suicide

Dubravka Jancic; Fayaz Seifuddin; Peter P. Zandi; James B. Potash; Virginia L. Willour

doi:10.1016/j.psychres.2012.06.001

Association study of X chromosome SNPs in attempted suicide

Dubravka Jancic, Fayaz Seifuddin, Peter P. Zandi, James B. Potash, Virginia L. Willour

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10^-4) and GRIA3 (P=4.01×10^-4). These findings highlight the need for larger sample sets and meta-analytic approaches.

Original language	English (US)
Pages (from-to)	1044-1046
Number of pages	3
Journal	Psychiatry research
Volume	200
Issue number	2-3
DOIs	https://doi.org/10.1016/j.psychres.2012.06.001
State	Published - Dec 30 2012

Keywords

GWAS
Sex chromosome
Suicidal behavior

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.psychres.2012.06.001

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title = "Association study of X chromosome SNPs in attempted suicide",

abstract = "We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10-4) and GRIA3 (P=4.01×10-4). These findings highlight the need for larger sample sets and meta-analytic approaches.",

keywords = "GWAS, Sex chromosome, Suicidal behavior",

author = "Dubravka Jancic and Fayaz Seifuddin and Zandi, {Peter P.} and Potash, {James B.} and Willour, {Virginia L.}",

note = "Funding Information: This work was supported by grants from the National Institute of Mental Health ( MH079240 to V.L.W.) and the American Foundation for Suicide Prevention (V.L.W). ",

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T1 - Association study of X chromosome SNPs in attempted suicide

AU - Jancic, Dubravka

AU - Seifuddin, Fayaz

AU - Zandi, Peter P.

AU - Potash, James B.

AU - Willour, Virginia L.

N1 - Funding Information: This work was supported by grants from the National Institute of Mental Health ( MH079240 to V.L.W.) and the American Foundation for Suicide Prevention (V.L.W).

PY - 2012/12/30

Y1 - 2012/12/30

N2 - We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10-4) and GRIA3 (P=4.01×10-4). These findings highlight the need for larger sample sets and meta-analytic approaches.

AB - We report the results of a high-density attempted suicide association study of the X chromosome, which genotyped 23,141 SNPs on 983 attempters and 1143 non-attempters and generated modest evidence for association for SH3KBP1 (P=1.07×10-4) and GRIA3 (P=4.01×10-4). These findings highlight the need for larger sample sets and meta-analytic approaches.

KW - GWAS

KW - Sex chromosome

KW - Suicidal behavior

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Association study of X chromosome SNPs in attempted suicide

Abstract

Keywords

ASJC Scopus subject areas

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